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Epigenetic alterations of the BDNF gene in combat-related post-traumatic stress disorder

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dc.contributor.author강지인-
dc.contributor.author김세주-
dc.date.accessioned2017-11-02T08:06:22Z-
dc.date.available2017-11-02T08:06:22Z-
dc.date.issued2017-
dc.identifier.issn0001-690X-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154083-
dc.description.abstractOBJECTIVE: Brain-derived neurotrophic factor (BDNF) plays a crucial role in modulating resilience and vulnerability to stress. The aim of this study was to investigate whether epigenetic regulation of the BDNF gene is a biomarker of post-traumatic stress disorder (PTSD) development among veterans exposed to combat in the Vietnam War. METHODS: Using the Clinician-Administered PTSD Scale, combat veterans were grouped into those with (n = 126) and without (n = 122) PTSD. DNA methylation levels at four CpG sites within the BDNF promoter I region were quantified in the peripheral blood using pyrosequencing. The effects of BDNF DNA methylation levels and clinical variables on the diagnosis of PTSD were tested using binary logistic regression analysis. RESULTS: Subjects with PTSD showed a higher DNA methylation of four CpG sites at the BDNF promoter compared with those without PTSD. High methylation levels at the BDNF promoter CpG site, high combat exposure, and alcohol problems were significantly associated with PTSD diagnosis. CONCLUSIONS: This study demonstrated an association between higher DNA methylation of the BDNF promoter and PTSD diagnosis in combat-exposed individuals. Our findings suggest that altered BDNF methylation may be a valuable biomarker of PTSD after trauma exposure.-
dc.description.statementOfResponsibilityrestriction-
dc.publisherWiley-Blackwell-
dc.relation.isPartOfACTA PSYCHIATRICA SCANDINAVICA-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHBrain-Derived Neurotrophic Factor/genetics*-
dc.subject.MESHCombat Disorders/diagnosis*-
dc.subject.MESHCombat Disorders/genetics-
dc.subject.MESHCpG Islands-
dc.subject.MESHDNA Methylation*-
dc.subject.MESHEpigenesis, Genetic-
dc.subject.MESHGenetic Association Studies-
dc.subject.MESHGenetic Predisposition to Disease-
dc.subject.MESHHumans-
dc.subject.MESHLogistic Models-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPromoter Regions, Genetic*-
dc.subject.MESHPsychiatric Status Rating Scales-
dc.titleEpigenetic alterations of the BDNF gene in combat-related post-traumatic stress disorder-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Psychiatry-
dc.contributor.googleauthorT. Y. Kim-
dc.contributor.googleauthorS. J. Kim-
dc.contributor.googleauthorH. G. Chung-
dc.contributor.googleauthorJ. H. Choi-
dc.contributor.googleauthorS. H. Kim-
dc.contributor.googleauthorJ. I. Kang-
dc.identifier.doi10.1111/acps.12675-
dc.contributor.localIdA00604-
dc.contributor.localIdA00084-
dc.relation.journalcodeJ00032-
dc.identifier.eissn1600-0447-
dc.identifier.pmid27886370-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1111/acps.12675/abstract-
dc.subject.keywordBDNF-
dc.subject.keywordDNA methylation-
dc.subject.keywordepigenetics-
dc.subject.keywordpost-traumatic stress disorder-
dc.subject.keywordtrauma-
dc.contributor.alternativeNameKang, Jee In-
dc.contributor.alternativeNameKim, Se Joo-
dc.contributor.affiliatedAuthorKim, Se Joo-
dc.contributor.affiliatedAuthorKang, Jee In-
dc.citation.titleActa Psychiatrica Scandinavica-
dc.citation.volume135-
dc.citation.number2-
dc.citation.startPage170-
dc.citation.endPage179-
dc.identifier.bibliographicCitationACTA PSYCHIATRICA SCANDINAVICA, Vol.135(2) : 170-179, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid41577-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers

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