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Impact of the ASA Physical Status Score on Adjuvant Chemotherapy Eligibility and Survival of Upper Tract Urothelial Carcinoma Patients: a Multicenter Study

 Ho Won Kang  ;  Sung Pil Seo  ;  Won Tae Kim  ;  Yong-June Kim  ;  Seok Joong Yun  ;  Sang-Cheol Lee  ;  Young Deuk Choi  ;  Yun-Sok Ha  ;  Tae-Hwan Kim  ;  Tae Gyun Kwon  ;  Seok-Soo Byun  ;  Seong Uk Jeh  ;  Wun-Jae Kim 
 JOURNAL OF KOREAN MEDICAL SCIENCE, Vol.32(2) : 335-342, 2017 
Journal Title
Issue Date
Aged ; Antineoplastic Agents/therapeutic use ; Carcinoma, Transitional Cell/drug therapy ; Carcinoma, Transitional Cell/mortality* ; Carcinoma, Transitional Cell/pathology ; Chemotherapy, Adjuvant ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Neoplasm Staging ; Nephrectomy ; Proportional Hazards Models ; Retrospective Studies ; Urologic Neoplasms/drug therapy ; Urologic Neoplasms/mortality* ; Urologic Neoplasms/pathology
Nephroureterectomy ; Physical Status Classification ; Survival ; Upper Urinary Tract ; Urothelial Carcinoma
The aim of the present multi-institutional study was to assess the influence of the American Society of Anesthesiologists Physical Status (ASA-PS) classification on adjuvant chemotherapy eligibility and survival in a multi-institutional cohort of patients treated with radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). We retrospectively reviewed data from 416 patients who underwent RNU for UTUC at four Korean institutions between 2001 and 2013. The ASA-PS classification was obtained from the anesthesia chart. Locally advanced UTUC was defined as ≥ pT3 and/or pN1 disease. The influence of ASA-PS score on survival was evaluated by Kaplan-Meier analyses and a multivariate Cox regression model. Patients with a higher ASA-PS class were less likely to be eligible for adjuvant chemotherapy in locally advanced UTUC (P = 0.016). Kaplan-Meier estimates showed that the high-risk ASA-PS group has a poorer overallsurvival (OS) and cancer-specific survival (CSS) compared to low risk ASA-PS groups in both the total and locally advanced UTUC cohorts. Based on multivariate Cox regression analysis, the high-risk ASA-PS category was an independent predictor for overall mortality (OM) (hazard ratio [HR], 1.919; 95% confidence interval [CI], 1.017–3.619; P = 0.044) and cancer-specific mortality (CSM) (HR, 2.120; 95% CI, 1.023–4.394; P = 0.043). In conclusion, high-risk ASA-PS score was independently associated with a lower survival rate in patients with UTUC after RNU. However, the influence of ASA-PS classification on survival was limited to locally advanced UTUC. The lower eligibility of patients in the high-risk ASA category for adjuvant chemotherapy may contribute to the lower survival rate in this group.
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1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
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