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Impact of the ASA Physical Status Score on Adjuvant Chemotherapy Eligibility and Survival of Upper Tract Urothelial Carcinoma Patients: a Multicenter Study

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dc.contributor.author최영득-
dc.date.accessioned2017-11-02T08:05:50Z-
dc.date.available2017-11-02T08:05:50Z-
dc.date.issued2017-
dc.identifier.issn1011-8934-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154070-
dc.description.abstractThe aim of the present multi-institutional study was to assess the influence of the American Society of Anesthesiologists Physical Status (ASA-PS) classification on adjuvant chemotherapy eligibility and survival in a multi-institutional cohort of patients treated with radical nephroureterectomy (RNU) for upper tract urothelial carcinoma (UTUC). We retrospectively reviewed data from 416 patients who underwent RNU for UTUC at four Korean institutions between 2001 and 2013. The ASA-PS classification was obtained from the anesthesia chart. Locally advanced UTUC was defined as ≥ pT3 and/or pN1 disease. The influence of ASA-PS score on survival was evaluated by Kaplan-Meier analyses and a multivariate Cox regression model. Patients with a higher ASA-PS class were less likely to be eligible for adjuvant chemotherapy in locally advanced UTUC (P = 0.016). Kaplan-Meier estimates showed that the high-risk ASA-PS group has a poorer overallsurvival (OS) and cancer-specific survival (CSS) compared to low risk ASA-PS groups in both the total and locally advanced UTUC cohorts. Based on multivariate Cox regression analysis, the high-risk ASA-PS category was an independent predictor for overall mortality (OM) (hazard ratio [HR], 1.919; 95% confidence interval [CI], 1.017–3.619; P = 0.044) and cancer-specific mortality (CSM) (HR, 2.120; 95% CI, 1.023–4.394; P = 0.043). In conclusion, high-risk ASA-PS score was independently associated with a lower survival rate in patients with UTUC after RNU. However, the influence of ASA-PS classification on survival was limited to locally advanced UTUC. The lower eligibility of patients in the high-risk ASA category for adjuvant chemotherapy may contribute to the lower survival rate in this group.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisher대한의학회(The Korean Academy of Medical Sciences)-
dc.relation.isPartOfJOURNAL OF KOREAN MEDICAL SCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHAntineoplastic Agents/therapeutic use-
dc.subject.MESHCarcinoma, Transitional Cell/drug therapy-
dc.subject.MESHCarcinoma, Transitional Cell/mortality*-
dc.subject.MESHCarcinoma, Transitional Cell/pathology-
dc.subject.MESHChemotherapy, Adjuvant-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHNephrectomy-
dc.subject.MESHProportional Hazards Models-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHUrologic Neoplasms/drug therapy-
dc.subject.MESHUrologic Neoplasms/mortality*-
dc.subject.MESHUrologic Neoplasms/pathology-
dc.titleImpact of the ASA Physical Status Score on Adjuvant Chemotherapy Eligibility and Survival of Upper Tract Urothelial Carcinoma Patients: a Multicenter Study-
dc.typeArticle-
dc.publisher.locationKorea (South)-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Urology-
dc.contributor.googleauthorHo Won Kang-
dc.contributor.googleauthorSung Pil Seo-
dc.contributor.googleauthorWon Tae Kim-
dc.contributor.googleauthorYong-June Kim-
dc.contributor.googleauthorSeok Joong Yun-
dc.contributor.googleauthorSang-Cheol Lee-
dc.contributor.googleauthorYoung Deuk Choi-
dc.contributor.googleauthorYun-Sok Ha-
dc.contributor.googleauthorTae-Hwan Kim-
dc.contributor.googleauthorTae Gyun Kwon-
dc.contributor.googleauthorSeok-Soo Byun-
dc.contributor.googleauthorSeong Uk Jeh-
dc.contributor.googleauthorWun-Jae Kim-
dc.identifier.doi10.3346/jkms.2017.32.2.335-
dc.contributor.localIdA04111-
dc.relation.journalcodeJ01517-
dc.identifier.eissn1598-6357-
dc.identifier.pmid28049247-
dc.subject.keywordNephroureterectomy-
dc.subject.keywordPhysical Status Classification-
dc.subject.keywordSurvival-
dc.subject.keywordUpper Urinary Tract-
dc.subject.keywordUrothelial Carcinoma-
dc.contributor.alternativeNameChoi, Young Deuk-
dc.contributor.affiliatedAuthorChoi, Young Deuk-
dc.citation.titleJournal of Korean Medical Science-
dc.citation.volume32-
dc.citation.number2-
dc.citation.startPage335-
dc.citation.endPage342-
dc.identifier.bibliographicCitationJOURNAL OF KOREAN MEDICAL SCIENCE, Vol.32(2) : 335-342, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid41564-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers

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