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Lack of association between LRRK2 G2385R and cognitive dysfunction in Korean patients with Parkinson's disease

 Jeong Hoon Hong  ;  Yue Kyung Kim  ;  Jae Seol Park  ;  Ji Eun Lee  ;  Mi Sun Oh  ;  Eun Joo Chung  ;  Jeong-Yeon Kim  ;  Young-Hee Sung  ;  Chul Hyoung Lyoo  ;  Jae Hyeok Lee  ;  Do-Young Kwon  ;  Hyun Sook Kim  ;  Hae-Won Shin  ;  Sun Ah Park  ;  In-Seok Park  ;  Joong-Seok Kim  ;  Phil Hyu Lee  ;  Seong-Beom Koh  ;  Jong Sam Baik  ;  Sang Jin Kim  ;  Hyeo-Il Ma  ;  Jae Woo Kim  ;  Yun Joong Kim 
 Journal of Clinical Neuroscience, Vol.36 : 108-113, 2017 
Journal Title
 Journal of Clinical Neuroscience 
Issue Date
Aged ; Case-Control Studies ; Cognitive Dysfunction/complications ; Cognitive Dysfunction/genetics* ; Female ; Humans ; Leucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics* ; Male ; Middle Aged ; Parkinson Disease/complications ; Parkinson Disease/genetics* ; Polymorphism, Single Nucleotide* ; Republic of Korea
Cognitive impairment ; Genetic risk factor ; Idiopathic Parkinson’s disease ; Leucine-rich repeat kinase 2 ; Polymorphism
Aside from the glucocerebrosidase gene, the genetic risk factors for cognitive decline in Parkinson's disease (PD) are controversial. We investigated whether the G2385R polymorphism in leucine-rich repeat kinase 2 gene (LRRK2), a risk variant for the development of PD in East Asians, is associated with cognitive dysfunction in PD. We recruited 299 PD patients, consisting of 23 carriers and 276 non-carriers of LRRK2 G2385R, from 14 centers. Global cognitive function was assessed using the Mini-Mental State Examination (MMSE) or the Montreal Cognitive Assessment (MoCA). PD with cognitive dysfunction was defined as an MMSE Z score that, adjusting for age at study entry and years of education, was below -1.0 standard deviations. In multivariate analysis, PD duration, age at study entry and depression were significant risk factors for cognitive dysfunction as assessed by MMSE performance or the MoCA. In linear regression analysis of the association between MMSE Z scores and PD duration, there was no significant difference associated with the LRRK2 G2385R genotype. The interaction terms between PD duration and the LRRK2 G2385R genotype were not significant for the MMSE Z score but were significant for the MoCA. In conclusion, the LRRK2 G2385R genotype may not be associated with cognitive dysfunction in PD.
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1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers
Yonsei Authors
Lyoo, Chul Hyoung(류철형) ORCID logo https://orcid.org/0000-0003-2231-672X
Lee, Phil Hyu(이필휴) ORCID logo https://orcid.org/0000-0001-9931-8462
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