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Lack of association between LRRK2 G2385R and cognitive dysfunction in Korean patients with Parkinson's disease

DC FieldValueLanguage
dc.contributor.author류철형-
dc.contributor.author이필휴-
dc.date.accessioned2017-11-02T08:05:20Z-
dc.date.available2017-11-02T08:05:20Z-
dc.date.issued2017-
dc.identifier.issn0967-5868-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/154060-
dc.description.abstractAside from the glucocerebrosidase gene, the genetic risk factors for cognitive decline in Parkinson's disease (PD) are controversial. We investigated whether the G2385R polymorphism in leucine-rich repeat kinase 2 gene (LRRK2), a risk variant for the development of PD in East Asians, is associated with cognitive dysfunction in PD. We recruited 299 PD patients, consisting of 23 carriers and 276 non-carriers of LRRK2 G2385R, from 14 centers. Global cognitive function was assessed using the Mini-Mental State Examination (MMSE) or the Montreal Cognitive Assessment (MoCA). PD with cognitive dysfunction was defined as an MMSE Z score that, adjusting for age at study entry and years of education, was below -1.0 standard deviations. In multivariate analysis, PD duration, age at study entry and depression were significant risk factors for cognitive dysfunction as assessed by MMSE performance or the MoCA. In linear regression analysis of the association between MMSE Z scores and PD duration, there was no significant difference associated with the LRRK2 G2385R genotype. The interaction terms between PD duration and the LRRK2 G2385R genotype were not significant for the MMSE Z score but were significant for the MoCA. In conclusion, the LRRK2 G2385R genotype may not be associated with cognitive dysfunction in PD.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherChurchill Livingstone-
dc.relation.isPartOfJOURNAL OF CLINICAL NEUROSCIENCE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAged-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHCognitive Dysfunction/complications-
dc.subject.MESHCognitive Dysfunction/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHLeucine-Rich Repeat Serine-Threonine Protein Kinase-2/genetics*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHParkinson Disease/complications-
dc.subject.MESHParkinson Disease/genetics*-
dc.subject.MESHPolymorphism, Single Nucleotide*-
dc.subject.MESHRepublic of Korea-
dc.titleLack of association between LRRK2 G2385R and cognitive dysfunction in Korean patients with Parkinson's disease-
dc.typeArticle-
dc.publisher.locationScotland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurology-
dc.contributor.googleauthorJeong Hoon Hong-
dc.contributor.googleauthorYue Kyung Kim-
dc.contributor.googleauthorJae Seol Park-
dc.contributor.googleauthorJi Eun Lee-
dc.contributor.googleauthorMi Sun Oh-
dc.contributor.googleauthorEun Joo Chung-
dc.contributor.googleauthorJeong-Yeon Kim-
dc.contributor.googleauthorYoung-Hee Sung-
dc.contributor.googleauthorChul Hyoung Lyoo-
dc.contributor.googleauthorJae Hyeok Lee-
dc.contributor.googleauthorDo-Young Kwon-
dc.contributor.googleauthorHyun Sook Kim-
dc.contributor.googleauthorHae-Won Shin-
dc.contributor.googleauthorSun Ah Park-
dc.contributor.googleauthorIn-Seok Park-
dc.contributor.googleauthorJoong-Seok Kim-
dc.contributor.googleauthorPhil Hyu Lee-
dc.contributor.googleauthorSeong-Beom Koh-
dc.contributor.googleauthorJong Sam Baik-
dc.contributor.googleauthorSang Jin Kim-
dc.contributor.googleauthorHyeo-Il Ma-
dc.contributor.googleauthorJae Woo Kim-
dc.contributor.googleauthorYun Joong Kim-
dc.identifier.doi10.1016/j.jocn.2016.10.013-
dc.contributor.localIdA03270-
dc.contributor.localIdA01333-
dc.relation.journalcodeJ01328-
dc.identifier.eissn1532-2653-
dc.identifier.pmid27839916-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0967586816301229-
dc.subject.keywordCognitive impairment-
dc.subject.keywordGenetic risk factor-
dc.subject.keywordIdiopathic Parkinson’s disease-
dc.subject.keywordLeucine-rich repeat kinase 2-
dc.subject.keywordPolymorphism-
dc.contributor.alternativeNameLyoo, Chul Hyoung-
dc.contributor.alternativeNameLee, Phil Hyu-
dc.contributor.affiliatedAuthorLee, Phil Hyu-
dc.contributor.affiliatedAuthorLyoo, Chul Hyoung-
dc.citation.titleJournal of Clinical Neuroscience-
dc.citation.volume36-
dc.citation.startPage108-
dc.citation.endPage113-
dc.identifier.bibliographicCitationJOURNAL OF CLINICAL NEUROSCIENCE, Vol.36 : 108-113, 2017-
dc.date.modified2017-11-01-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurology (신경과학교실) > 1. Journal Papers

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