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Intestinal Glycolysis Visualized by FDG PET/CT Correlates With Glucose Decrement After Gastrectomy

Authors
 Cheol Ryong Ku  ;  Narae Lee  ;  Jae Won Hong  ;  In Gyu Kwon  ;  Woo Jin Hyung  ;  Sung Hoon Noh  ;  Eun Jig Lee  ;  Mijin Yun  ;  Arthur Cho 
Citation
 Diabetes, Vol.66(2) : 385-391, 2017 
Journal Title
 Diabetes 
ISSN
 0012-1797 
Issue Date
2017
MeSH
Aged ; Diabetes Mellitus/diagnostic imaging* ; Diabetes Mellitus/metabolism ; Female ; Fluorodeoxyglucose F18 ; Gastrectomy/methods* ; Glucose/metabolism* ; Glycolysis* ; Humans ; Intestines/diagnostic imaging* ; Intestines/metabolism ; Male ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Positron Emission Tomography Computed Tomography ; Radiopharmaceuticals ; Retrospective Studies ; Stomach Neoplasms/surgery
Abstract
Gastrectomy method is known to influence glucose homeostasis. 18F-fluoro-2-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) images acquired after gastrectomy often reveals newly developed physiological small bowel uptake. We correlated newly developed small bowel FDG uptake and glucose homeostasis in postgastrectomy gastric cancer patients. We retrospectively analyzed 239 patients without diabetes who underwent staging and follow-up FDG PET/CT scanning before and after gastrectomy for gastric cancer. Postoperative small bowel glycolysis was quantified by recording intestinal total lesion glycolysis (TLG). TLG was assessed with regard to surgical method (Billroth I, Billroth II [BII], Roux-en-Y [RY]), fasting glucose decrement (≥10 mg/dL), and other clinical factors. Patients' weight, fasting glucose, cholesterol, TLG, and body fat levels significantly decreased after surgery. The glucose decrement was significantly associated with fasting glucose, surgical methods, total cholesterol, TLG, and total body fat on univariate analysis. Multivariate analysis showed that BII surgery (odds ratio 6.51) and TLG (odds ratio 3.17) were significantly correlated with glucose decrement. High small bowel glycolysis (TLG >42.0 g) correlated with glucose decrement in RY patients. Newly developed small bowel glycolysis on postgastrectomy FDG PET/CT scanning is correlated with a glucose decrement. These findings suggest a potential role of FDG PET/CT scanning in the evaluation of small bowel glycolysis and glucose control.
Full Text
http://diabetes.diabetesjournals.org/content/66/2/385.long
DOI
10.2337/db16-1000
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
구철룡(Ku, Cheol Ryong) ORCID logo https://orcid.org/0000-0001-8693-9630
노성훈(Noh, Sung Hoon) ORCID logo https://orcid.org/0000-0003-4386-6886
윤미진(Yun, Mi Jin) ORCID logo https://orcid.org/0000-0002-1712-163X
이나래(Lee, Na Rae)
이은직(Lee, Eun Jig) ORCID logo https://orcid.org/0000-0002-9876-8370
조응혁(Cho, Arthur Eung Hyuck) ORCID logo https://orcid.org/0000-0001-8670-2473
형우진(Hyung, Woo Jin) ORCID logo https://orcid.org/0000-0002-8593-9214
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/154023
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