0 504

Cited 3 times in

Different subtypes of epithelioid sarcoma and their clinical implication: long-term multi-institutional experience with a rare sarcoma

 Chan Kim  ;  Kwai Han Yoo  ;  Min Hwan Kim  ;  Hong Jae Chon  ;  Soon Il Lee  ;  Hyo Jin Lee  ;  Sujin Koh  ;  Ha Yeon Lee  ;  Hye Ran Lee  ;  Kyung Sik Kim  ;  Young Deuk Choi  ;  Sun Young Rha  ;  Su Jin Lee  ;  Hyo Song Kim 
 APMIS, Vol.125(3) : 223-229, 2017 
Journal Title
Issue Date
Adolescent ; Adult ; Aged ; Aged, 80 and over ; Chemotherapy, Adjuvant ; Child ; Child, Preschool ; Combined Modality Therapy ; Female ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Prognosis ; Radiotherapy, Adjuvant ; Recurrence ; Retrospective Studies ; Sarcoma/mortality ; Sarcoma/pathology* ; Sarcoma/therapy ; Young Adult
Epithelioid sarcoma ; chemotherapy ; clinical outcome ; radiotherapy ; subtype
Epithelioid sarcoma (ES) is a very rare soft-tissue sarcoma with a high tendency of recurrence and metastasis. We analyzed clinical features of ES and aimed to identify the potential role of radio- and chemotherapy in ES. Fifty-five patients diagnosed with ES between 1997 and 2014 were enrolled from seven tertiary hospitals in Korean Cancer Research Group. The clinical variables were retrospectively reviewed and analyzed. Forty-six (84%) patients underwent surgical resection of ES, and among them, 27 experienced recurrence. In these patients, resection margin status and adjuvant radiotherapy were independent prognostic factors for longer recurrence-free survival (RFS), while adjuvant chemotherapy did not influence RFS. Twenty-two (40%) patients received palliative chemotherapy for metastatic or recurrent ES, and in these patients, palliative chemotherapy was the only independent prognostic factor for longer overall survival. Intriguingly, the clinical benefit of radio- and chemotherapy was observable only in proximal ES, but not in extremity ES, indicating that subtypes of ES might respond to radio- or chemotherapy differently. Proximal ES seems to benefits more from active anticancer treatment than conventional extremity ES. The aggressive characteristics of proximal ES could be overcome with an optimal multimodal treatment.
Full Text
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Urology (비뇨의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Kyung Sik(김경식) ORCID logo https://orcid.org/0000-0001-9498-284X
Kim, Min Hwan(김민환) ORCID logo https://orcid.org/0000-0002-1595-6342
Kim, Hyo Song(김효송) ORCID logo https://orcid.org/0000-0002-0625-9828
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Choi, Young Deuk(최영득) ORCID logo https://orcid.org/0000-0002-8545-5797
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.