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Tumor stroma with senescence-associated secretory phenotype in steatohepatitic hepatocellular carcinoma

DC FieldValueLanguage
dc.contributor.author고명주-
dc.contributor.author박영년-
dc.contributor.author유정은-
dc.contributor.author이형진-
dc.contributor.author최진섭-
dc.contributor.author남지해-
dc.date.accessioned2017-11-01T09:04:40Z-
dc.date.available2017-11-01T09:04:40Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/153991-
dc.description.abstractSenescence secretome was recently reported to promote liver cancer in an obese mouse model. Steatohepatitic hepatocellular carcinoma (SH-HCC), a new variant of HCC, has been found in metabolic syndrome patients, and pericellular fibrosis, a characteristic feature of SH-HCC, suggests that alteration of the tumor stroma might play an important role in SH-HCC development. Clinicopathological characteristics and tumor stroma showing senescence and senescence-associated secretory phenotype (SASP) were investigated in 21 SH-HCCs and 34 conventional HCCs (C-HCCs). The expression of α-smooth muscle actin (α-SMA), p21Waf1/Cif1, γ-H2AX, and IL-6 was investigated by immunohistochemistry or immunofluorescence. SH-HCCs were associated with older age, higher body mass index, and a higher incidence of metabolic syndrome, compared to C-HCC (P <0.05, all). The numbers of α-SMA-positive cancer-associated fibroblasts (CAFs) (P = 0.049) and α-SMA-positive CAFs co-expressing p21Waf1/Cif1 (P = 0.038), γ-H2AX (P = 0.065), and IL-6 (P = 0.048) were greater for SH-HCCs than C-HCCs. Additionally, non-tumoral liver from SH-HCCs showed a higher incidence of non-alcoholic fatty liver disease and a higher number of α-SMA-positive stellate cells expressing γ-H2AX and p21Waf1/Cif1 than that from C-HCCs (P <0.05, all). In conclusion, SH-HCCs are considered to occur more frequently in metabolic syndrome patients. Therein, senescent and damaged CAFs, as well as non-tumoral stellate cells, expressing SASP including IL-6 may contribute to the development of SH-HCC.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/pdf-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHActins/genetics-
dc.subject.MESHActins/metabolism-
dc.subject.MESHAged-
dc.subject.MESHAging*-
dc.subject.MESHCarcinoma, Hepatocellular/complications-
dc.subject.MESHCarcinoma, Hepatocellular/mortality-
dc.subject.MESHCarcinoma, Hepatocellular/pathology*-
dc.subject.MESHCyclin-Dependent Kinase Inhibitor p21/genetics-
dc.subject.MESHCyclin-Dependent Kinase Inhibitor p21/metabolism-
dc.subject.MESHDisease-Free Survival-
dc.subject.MESHFemale-
dc.subject.MESHHistones/genetics-
dc.subject.MESHHistones/metabolism-
dc.subject.MESHHumans-
dc.subject.MESHImmunohistochemistry-
dc.subject.MESHInterleukin-6/genetics-
dc.subject.MESHInterleukin-6/metabolism-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHLiver/metabolism-
dc.subject.MESHLiver/pathology-
dc.subject.MESHLiver Neoplasms/complications-
dc.subject.MESHLiver Neoplasms/mortality-
dc.subject.MESHLiver Neoplasms/pathology*-
dc.subject.MESHMale-
dc.subject.MESHMetabolic Syndrome/complications-
dc.subject.MESHMetabolic Syndrome/pathology-
dc.subject.MESHMicroscopy, Fluorescence-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/complications-
dc.subject.MESHNon-alcoholic Fatty Liver Disease/pathology*-
dc.titleTumor stroma with senescence-associated secretory phenotype in steatohepatitic hepatocellular carcinoma-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthorJee San Lee-
dc.contributor.googleauthorJeong Eun Yoo-
dc.contributor.googleauthorHaeryoung Kim-
dc.contributor.googleauthorHyungjin Rhee-
dc.contributor.googleauthorMyoung Ju Koh-
dc.contributor.googleauthorJi Hae Nahm-
dc.contributor.googleauthorJin Sub Choi-
dc.contributor.googleauthorKee-Ho Lee-
dc.contributor.googleauthorYoung Nyun Park-
dc.identifier.doi10.1371/journal.pone.0171922-
dc.contributor.localIdA01563-
dc.contributor.localIdA04775-
dc.contributor.localIdA05171-
dc.contributor.localIdA04199-
dc.contributor.localIdA04875-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid28273155-
dc.contributor.alternativeNameKoh, Myoung Ju-
dc.contributor.alternativeNamePark, Young Nyun-
dc.contributor.alternativeNameYoo, Jeong Eun-
dc.contributor.alternativeNameRhee, Hyungjin-
dc.contributor.alternativeNameChoi, Jin Sub-
dc.contributor.affiliatedAuthorPark, Young Nyun-
dc.contributor.affiliatedAuthorYoo, Jeong Eun-
dc.contributor.affiliatedAuthorRhee, Hyungjin-
dc.contributor.affiliatedAuthorChoi, Jin Sub-
dc.contributor.affiliatedAuthorKoh, Myoung Ju-
dc.citation.titlePLoS One-
dc.citation.volume12-
dc.citation.number3-
dc.citation.startPagee0171922-
dc.identifier.bibliographicCitationPLOS ONE, Vol.12(3) : e0171922, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid44140-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > BioMedical Science Institute (의생명과학부) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers

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