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Prevalence and prognostic implications of psychological distress in patients with gastric cancer

Authors
 Gun Min Kim  ;  Seung Jun Kim  ;  Su Kyung Song  ;  Hye Ryun Kim  ;  Beo Deul Kang  ;  Sung Hoon Noh  ;  Hyun Cheol Chung  ;  Kyung Ran Kim  ;  Sun Young Rha 
Citation
 BMC CANCER, Vol.17(1) : 283, 2017 
Journal Title
 BMC CANCER 
Issue Date
2017
MeSH
Adult ; Aged ; Aged, 80 and over ; Disease-Free Survival ; Female ; Humans ; Logistic Models ; Male ; Middle Aged ; Neoplasm Staging ; Odds Ratio ; Prevalence ; Prognosis ; Quality of Life/psychology ; Stomach ; eoplasms/pathology* ; Stomach Neoplasms/psychology* ; Stress, Psychological/epidemiology* ; Survival Analysis ; Young Adult
Keywords
Gastric cancer ; Prognosis ; Psychological distress ; Survival
Abstract
BACKGROUND: The aim of this study was to investigate the prevalence and prognostic significance of psychological distress in gastric cancer patients. METHODS: The study population included 229 gastric cancer patients visiting Yonsei Cancer Center between November 2009 and March 2011. The distress was measured by available tools including the Modified Distress Thermometer (MDT), Hospital Anxiety and Depression Scale (HADS), and Center for Epidemiologic Studies-Depression Scale (CES-D). Patients with psychological distress were defined as those who scored above the cut-off values in both the MDT and either one of the HADS or CES-D. RESULTS: The median age of patients was 56 (range, 20 to 86) and 97 (42.4%) patients were with stage IV disease status at enrollment. The overall prevalence of psychological distress was 33.6% (95% CI: 27.5-39.8%) in 229 gastric cancer patients. In multiple logistic regression analysis, lower education level (odds ratio [OR] 2.39; 95% confidence interval [CI] 1.11-5.17, P = 0.026) and higher disease stage (OR 2.72; 95% CI 1.47-5.03, P = 0.001) were associated with psychological distress. In stage I-III disease, patients with psychological distress had worse disease-free survival (DFS) (5-year DFS rate: 60% vs 76%, P = 0.49) compared with those without psychological distress. In stage IV disease (n = 97), patients with psychological distress showed poorer overall survival than those without psychological distress (median OS (Overall Survival): 12.2 vs. 13.8 months, P = 0.019). CONCLUSION: Psychological distress is common in patients with all stages of gastric cancer and is associated with worse outcomes.
Files in This Item:
T201701378.pdf Download
DOI
10.1186/s12885-017-3260-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Gun Min(김건민) ORCID logo https://orcid.org/0000-0001-9167-8682
Kim, Kyung Ran(김경란) ORCID logo https://orcid.org/0000-0001-8375-1851
Kim, Hye Ryun(김혜련) ORCID logo https://orcid.org/0000-0002-1842-9070
Noh, Sung Hoon(노성훈) ORCID logo https://orcid.org/0000-0003-4386-6886
Rha, Sun Young(라선영) ORCID logo https://orcid.org/0000-0002-2512-4531
Song Su Kyung(송수경)
Chung, Hyun Cheol(정현철) ORCID logo https://orcid.org/0000-0002-0920-9471
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/153679
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