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Depth of response is a significant predictor for long-term outcome in advanced gastric cancer patients treated with trastuzumab

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dc.contributor.author김승섭-
dc.contributor.author김현기-
dc.contributor.author김효송-
dc.contributor.author라선영-
dc.contributor.author이충근-
dc.contributor.author임준석-
dc.contributor.author정민규-
dc.contributor.author정현철-
dc.contributor.author허수진-
dc.contributor.author박소희-
dc.date.accessioned2017-11-01T08:48:40Z-
dc.date.available2017-11-01T08:48:40Z-
dc.date.issued2017-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/153668-
dc.description.abstractPURPOSE: We aimed to determine and compare the predictive values of depth of response (DpR) and early tumor shrinkage (ETS) on long-term outcomes in gastric cancer patients treated with trastuzumab. RESULTS: From a total of 368 computed tomography examinations, DpR and ETS were evaluated. DpR was a significant tumor-size metric in predicting PFS and OS, and showed better discriminatory ability (higher Cτ indices, 0.6957 for PFS; 0.7191 for OS) than ETS. DpR ≥ 45% (vs. < 45%) was the optimal cutoff value, as it was best able to identify patients with longer PFS (median 9.0 vs. 6.3 months, hazard ratio [HR] = 0.608; 95% confidence interval [CI]: 0.335 to 1.104; P = 0.102) and OS (median 23.5 vs. 13.1 months, HR = 0.441; 95% CI: 0.203 to 0.955; P = 0.038). MATERIALS AND METHODS: Sixty-one gastric cancer patients who received first-line trastuzumab-based chemotherapy were assessed for DpR and ETS. We employed Kaplan-Meier estimates, log-rank tests, Cox proportional hazards regression models, time-dependent receiver operating characteristics, and Youden's J index to evaluate and determine cutoff values of DpR and ETS as predictors of progression-free survival (PFS) and overall survival (OS). CONCLUSIONS: DpR and ETS were significant predictors of long-term outcomes in gastric cancer patients treated with first-line trastuzumab. Validation in prospective trials with larger patient populations is needed.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherImpact Journals-
dc.relation.isPartOfONCOTARGET-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHAntineoplastic Agents, Immunological/administration & dosage-
dc.subject.MESHAntineoplastic Agents, Immunological/adverse effects-
dc.subject.MESHAntineoplastic Agents, Immunological/therapeutic use*-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/adverse effects-
dc.subject.MESHAntineoplastic Combined Chemotherapy Protocols/therapeutic use-
dc.subject.MESHBiomarkers, Tumor-
dc.subject.MESHFemale-
dc.subject.MESHHumans-
dc.subject.MESHKaplan-Meier Estimate-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoplasm Metastasis-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPrognosis-
dc.subject.MESHROC Curve-
dc.subject.MESHStomach Neoplasms/diagnosis*-
dc.subject.MESHStomach Neoplasms/drug therapy*-
dc.subject.MESHStomach Neoplasms/mortality-
dc.subject.MESHTrastuzumab/administration & dosage-
dc.subject.MESHTrastuzumab/adverse effects-
dc.subject.MESHTrastuzumab/therapeutic use*-
dc.subject.MESHTreatment Outcome-
dc.titleDepth of response is a significant predictor for long-term outcome in advanced gastric cancer patients treated with trastuzumab-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorChoong-Kun Lee-
dc.contributor.googleauthorSeung-Seob Kim-
dc.contributor.googleauthorSaemi Park-
dc.contributor.googleauthorChan Kim-
dc.contributor.googleauthorSu Jin Heo-
dc.contributor.googleauthorJoon Seok Lim-
dc.contributor.googleauthorHyunki Kim-
dc.contributor.googleauthorHyo Song Kim-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorHyun Cheol Chung-
dc.contributor.googleauthorSohee Park-
dc.contributor.googleauthorMinkyu Jung-
dc.identifier.doi10.18632/oncotarget.16099-
dc.contributor.localIdA01108-
dc.contributor.localIdA01202-
dc.contributor.localIdA01316-
dc.contributor.localIdA03259-
dc.contributor.localIdA03408-
dc.contributor.localIdA03606-
dc.contributor.localIdA03773-
dc.contributor.localIdA04355-
dc.contributor.localIdA01531-
dc.contributor.localIdA05097-
dc.relation.journalcodeJ02421-
dc.identifier.eissn1949-2553-
dc.identifier.pmid28415714-
dc.subject.keyworddepth of response-
dc.subject.keywordearly tumor shrinkage-
dc.subject.keywordgastric cancer-
dc.subject.keywordsurvival-
dc.subject.keywordtrastuzumab-
dc.contributor.alternativeNameKim, Seung Seob-
dc.contributor.alternativeNameKim, Hyun Ki-
dc.contributor.alternativeNameKim, Hyo Song-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameLee, Choong Kun-
dc.contributor.alternativeNameLim, Joon Seok-
dc.contributor.alternativeNameJung, Min Kyu-
dc.contributor.alternativeNameChung, Hyun Cheol-
dc.contributor.alternativeNameHeo, Su Jin-
dc.contributor.alternativeNamePark, So Hee-
dc.contributor.affiliatedAuthorKim, Hyun Ki-
dc.contributor.affiliatedAuthorKim, Hyo Song-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.contributor.affiliatedAuthorLee, Choong Kun-
dc.contributor.affiliatedAuthorLim, Joon Seok-
dc.contributor.affiliatedAuthorJung, Min Kyu-
dc.contributor.affiliatedAuthorChung, Hyun Cheol-
dc.contributor.affiliatedAuthorHeo, Su Jin-
dc.contributor.affiliatedAuthorPark, So Hee-
dc.contributor.affiliatedAuthorKim, Seung Seob-
dc.citation.titleOncotarget-
dc.citation.volume8-
dc.citation.number19-
dc.citation.startPage31169-
dc.citation.endPage31179-
dc.identifier.bibliographicCitationONCOTARGET , Vol.8(19) : 31169-31179, 2017-
dc.date.modified2017-11-01-
dc.identifier.rimsid42963-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers

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