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The prognostic role of CD68 and FoxP3 expression in patients with primary central nervous system lymphoma

 Hyunsoo Cho  ;  Se Hoon Kim  ;  Soo-Jeong Kim  ;  Jong Hee Chang  ;  Woo Ick Yang  ;  Chang-Ok Suh  ;  June-Won Cheong  ;  Yu Ri Kim  ;  Jung Yeon Lee  ;  Ji Eun Jang  ;  Yundeok Kim  ;  Yoo Hong Min  ;  Jin Seok Kim 
 Annals of Hematology, Vol.96(7) : 1163-1173, 2017 
Journal Title
 Annals of Hematology 
Issue Date
Adult ; Aged ; Antigens, CD/metabolism* ; Antigens, Differentiation, Myelomonocytic/metabolism* ; Antineoplastic Combined Chemotherapy Protocols/therapeutic use* ; Central Nervous System Neoplasms/metabolism ; Central Nervous System Neoplasms/pathology ; Central Nervous System Neoplasms/therapy* ; Combined Modality Therapy ; Female ; Forkhead Transcription Factors/metabolism* ; Hematopoietic Stem Cell Transplantation/methods* ; Humans ; Immunohistochemistry ; Kaplan-Meier Estimate ; Lymphoma/metabolism ; Lymphoma/pathology ; Lymphoma/therapy* ; Male ; Methotrexate/administration & dosage ; Middle Aged ; Multivariate Analysis ; Outcome Assessment (Health Care)/methods ; Outcome Assessment (Health Care)/statistics & numerical data ; Prognosis ; Proportional Hazards Models ; Retrospective Studies ; Transplantation, Autologous
Autologous stem cell transplantation ; CD68 ; FoxP3 ; Primary central nervous system lymphoma ; Tumor microenvironment
The prognostic role of CD68 and FoxP3 in primary central nervous system lymphoma (PCNSL) has not been evaluated. Thus, we examined the prognostic significance of CD68 and FoxP3 expression in tumor samples of 76 newly diagnosed immunocompetent PCNSL patients. All patients were treated initially with high-dose methotrexate (HD-MTX)-based chemotherapy, and 16 (21.1%) patients received upfront autologous stem cell transplantation (ASCT) consolidation. High expression of CD68 (>55 cells/high-power field) or FoxP3 (>15 cells/high-power field) was observed in 10 patients, respectively. High CD68 expression was associated with inferior overall survival (OS) and progression-free survival (PFS) in multivariate analysis (P = 0.023 and P = 0.021, respectively). In addition, we performed subgroup analysis based on upfront ASCT. High CD68 expression was also associated with inferior OS and PFS in multivariate analysis (P = 0.013 and P < 0.001, respectively) among patients who did not receive upfront ASCT (n = 60), but not in patients who received upfront ASCT. The expression of FoxP3 was not significantly associated with survival. Therefore, we identified a prognostic significance of high CD68 expression in PCNSL, which suggests a need for further clinical trials and biological studies on the role of PCNSL tumor microenvironment.
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1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
김세훈(Kim, Se Hoon) ORCID logo https://orcid.org/0000-0001-7516-7372
김수정(Kim, Soo Jeong) ORCID logo https://orcid.org/0000-0001-8859-3573
김유리(Kim, Yu Ri) ORCID logo https://orcid.org/0000-0001-5505-0142
김윤덕(Kim, Yun Deok) ORCID logo https://orcid.org/0000-0002-5336-7936
김진석(Kim, Jin Seok) ORCID logo https://orcid.org/0000-0001-8986-8436
민유홍(Min, Yoo Hong) ORCID logo https://orcid.org/0000-0001-8542-9583
서창옥(Suh, Chang Ok)
양우익(Yang, Woo Ick) ORCID logo https://orcid.org/0000-0002-6084-5019
이정연(Lee, Jung Yoen)
장종희(Chang, Jong Hee)
장지은(Jang, Ji Eun) ORCID logo https://orcid.org/0000-0001-8832-1412
정준원(Cheong, June-Won) ORCID logo https://orcid.org/0000-0002-1744-0921
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