154 260

Cited 2 times in

대장암의 분자 분류와 임상 적용

Other Titles
 Molecular Classification of Colorectal Cancers and Clinical Application 
Authors
 전소연  ;  김원규  ;  김호근 
Citation
 Korean Journal of Gastroenterology, Vol.68(6) : 297-302, 2016 
Journal Title
 Korean Journal of Gastroenterology 
ISSN
 1598-9992 
Issue Date
2016
MeSH
Adenocarcinoma/diagnosis ; Adenocarcinoma/metabolism ; Adenocarcinoma/pathology ; Biomarkers, Tumor/genetics ; Biomarkers, Tumor/metabolism* ; Colorectal Neoplasms/diagnosis* ; Colorectal Neoplasms/metabolism ; Colorectal Neoplasms/pathology ; Gene Expression Regulation, Neoplastic ; Humans ; Prognosis
Keywords
Colonic neoplasms ; Molecular medicine ; Molecular typing
Abstract
The molecular genetics of colorectal cancers (CRCs) is among the best understood of common human cancers. It is difficult to predict the prognosis and/or to predict chemoresponding in CRC patients. At present, prognosis is based predominantly on the tumor stage and pathological examination of the disease. Molecular classification of CRCs, based on genomics and transcriptomics, proposed that CRCs can be classified into at least three-to-six subtypes, depending on the gene expression pattern, and groups of marker genes representing to each subtype have also been reported. Gene expression-based subtyping is now widely accepted as a relevant source of disease stratification. We reviewed the previous studies on CRC subtyping, international consortium dedicated to large-scale data sharing and analytics recently established four consensus molecular subtypes with distinguishing features. Predictive markers identified in these studies are under investigation and large-scale clinical evaluations of molecular markers are currently in progress.
Files in This Item:
T201606172.pdf Download
DOI
10.4166/kjg.2016.68.6.297
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Won Kyu(김원규)
Kim, Hogeun(김호근)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/153113
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse

Links