Cited 2 times in
대장암의 분자 분류와 임상 적용
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 김원규 | - |
dc.contributor.author | 김호근 | - |
dc.date.accessioned | 2017-10-26T08:11:56Z | - |
dc.date.available | 2017-10-26T08:11:56Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1598-9992 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/153113 | - |
dc.description.abstract | The molecular genetics of colorectal cancers (CRCs) is among the best understood of common human cancers. It is difficult to predict the prognosis and/or to predict chemoresponding in CRC patients. At present, prognosis is based predominantly on the tumor stage and pathological examination of the disease. Molecular classification of CRCs, based on genomics and transcriptomics, proposed that CRCs can be classified into at least three-to-six subtypes, depending on the gene expression pattern, and groups of marker genes representing to each subtype have also been reported. Gene expression-based subtyping is now widely accepted as a relevant source of disease stratification. We reviewed the previous studies on CRC subtyping, international consortium dedicated to large-scale data sharing and analytics recently established four consensus molecular subtypes with distinguishing features. Predictive markers identified in these studies are under investigation and large-scale clinical evaluations of molecular markers are currently in progress. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | Korean | - |
dc.publisher | Korean Society of Gastroenterology | - |
dc.relation.isPartOf | Korean Journal of Gastroenterology | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adenocarcinoma/diagnosis | - |
dc.subject.MESH | Adenocarcinoma/metabolism | - |
dc.subject.MESH | Adenocarcinoma/pathology | - |
dc.subject.MESH | Biomarkers, Tumor/genetics | - |
dc.subject.MESH | Biomarkers, Tumor/metabolism* | - |
dc.subject.MESH | Colorectal Neoplasms/diagnosis* | - |
dc.subject.MESH | Colorectal Neoplasms/metabolism | - |
dc.subject.MESH | Colorectal Neoplasms/pathology | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Prognosis | - |
dc.title | 대장암의 분자 분류와 임상 적용 | - |
dc.title.alternative | Molecular Classification of Colorectal Cancers and Clinical Application | - |
dc.type | Article | - |
dc.publisher.location | Korea | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Pathology | - |
dc.contributor.googleauthor | 전소연 | - |
dc.contributor.googleauthor | 김원규 | - |
dc.contributor.googleauthor | 김호근 | - |
dc.identifier.doi | 10.4166/kjg.2016.68.6.297 | - |
dc.contributor.localId | A01183 | - |
dc.contributor.localId | A00764 | - |
dc.relation.journalcode | J02014 | - |
dc.relation.journalsince | 2011~ | - |
dc.identifier.pmid | 28025472 | - |
dc.relation.journalbefore | ~2010 Korean Journal of Gastroenterology (대한소화기학회지) | - |
dc.subject.keyword | Colonic neoplasms | - |
dc.subject.keyword | Molecular medicine | - |
dc.subject.keyword | Molecular typing | - |
dc.contributor.alternativeName | Kim, Won Kyu | - |
dc.contributor.alternativeName | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | Kim, Ho Keun | - |
dc.contributor.affiliatedAuthor | Kim, Won Kyu | - |
dc.citation.volume | 68 | - |
dc.citation.number | 6 | - |
dc.citation.startPage | 297 | - |
dc.citation.endPage | 302 | - |
dc.identifier.bibliographicCitation | Korean Journal of Gastroenterology, Vol.68(6) : 297-302, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 41115 | - |
dc.type.rims | ART | - |
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