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대장암의 분자 분류와 임상 적용

DC FieldValueLanguage
dc.contributor.author김원규-
dc.contributor.author김호근-
dc.date.accessioned2017-10-26T08:11:56Z-
dc.date.available2017-10-26T08:11:56Z-
dc.date.issued2016-
dc.identifier.issn1598-9992-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/153113-
dc.description.abstractThe molecular genetics of colorectal cancers (CRCs) is among the best understood of common human cancers. It is difficult to predict the prognosis and/or to predict chemoresponding in CRC patients. At present, prognosis is based predominantly on the tumor stage and pathological examination of the disease. Molecular classification of CRCs, based on genomics and transcriptomics, proposed that CRCs can be classified into at least three-to-six subtypes, depending on the gene expression pattern, and groups of marker genes representing to each subtype have also been reported. Gene expression-based subtyping is now widely accepted as a relevant source of disease stratification. We reviewed the previous studies on CRC subtyping, international consortium dedicated to large-scale data sharing and analytics recently established four consensus molecular subtypes with distinguishing features. Predictive markers identified in these studies are under investigation and large-scale clinical evaluations of molecular markers are currently in progress.-
dc.description.statementOfResponsibilityopen-
dc.languageKorean-
dc.publisherKorean Society of Gastroenterology-
dc.relation.isPartOfKorean Journal of Gastroenterology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/diagnosis-
dc.subject.MESHAdenocarcinoma/metabolism-
dc.subject.MESHAdenocarcinoma/pathology-
dc.subject.MESHBiomarkers, Tumor/genetics-
dc.subject.MESHBiomarkers, Tumor/metabolism*-
dc.subject.MESHColorectal Neoplasms/diagnosis*-
dc.subject.MESHColorectal Neoplasms/metabolism-
dc.subject.MESHColorectal Neoplasms/pathology-
dc.subject.MESHGene Expression Regulation, Neoplastic-
dc.subject.MESHHumans-
dc.subject.MESHPrognosis-
dc.title대장암의 분자 분류와 임상 적용-
dc.title.alternativeMolecular Classification of Colorectal Cancers and Clinical Application-
dc.typeArticle-
dc.publisher.locationKorea-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Pathology-
dc.contributor.googleauthor전소연-
dc.contributor.googleauthor김원규-
dc.contributor.googleauthor김호근-
dc.identifier.doi10.4166/kjg.2016.68.6.297-
dc.contributor.localIdA01183-
dc.contributor.localIdA00764-
dc.relation.journalcodeJ02014-
dc.relation.journalsince2011~-
dc.identifier.pmid28025472-
dc.relation.journalbefore~2010 Korean Journal of Gastroenterology (대한소화기학회지)-
dc.subject.keywordColonic neoplasms-
dc.subject.keywordMolecular medicine-
dc.subject.keywordMolecular typing-
dc.contributor.alternativeNameKim, Won Kyu-
dc.contributor.alternativeNameKim, Ho Keun-
dc.contributor.affiliatedAuthorKim, Ho Keun-
dc.contributor.affiliatedAuthorKim, Won Kyu-
dc.citation.volume68-
dc.citation.number6-
dc.citation.startPage297-
dc.citation.endPage302-
dc.identifier.bibliographicCitationKorean Journal of Gastroenterology, Vol.68(6) : 297-302, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid41115-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pathology (병리학교실) > 1. Journal Papers

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