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Treatment Outcomes of Patients Treated for Pulmonary Tuberculosis after Undergoing Gastrectomy

Authors
 In Young Jung  ;  Moo Hyun Kim  ;  Woo Yong Jeong  ;  Mi Young Ahn  ;  Yong Duk Jeon  ;  Hea Won Ahn  ;  Jin Young Ahn  ;  Je Eun Song  ;  Dong Hyun Oh  ;  Yong Chan Kim  ;  Eun Jin Kim  ;  Su Jin Jeong  ;  Nam Su Ku  ;  June Myung Kim  ;  Jun Yong Choi 
Citation
 Tohoku Journal of Experimental Medicine, Vol.240(4) : 281-286, 2016 
Journal Title
 Tohoku Journal of Experimental Medicine 
ISSN
 0040-8727 
Issue Date
2016
Abstract
Gastrectomy is a proxy of malnutrition, which may lead to increased risk for developing pulmonary tuberculosis (TB). Malabsorption in gastrectomy patients could lead to low serum levels of rifampicin, which may be related to higher treatment failure. However, there is limited information on treatment outcomes of TB in patients who have undergone gastrectomy. This study aims to determine treatment outcomes and adverse effects in patients treated for TB after undergoing gastrectomy for gastric cancer. During the study period, 112 patients were treated for active TB that developed after gastrectomy for gastric cancer. Among them, we selected 15 patients who were culture positive at initial diagnosis and had evidence of active TB on imaging studies; namely, the remaining 97 patients without initial culture or imaging studies were excluded. We thus performed a case-control study of gastric cancer patients treated for TB after undergoing gastrectomy (n = 15). The control group was defined as age- and sex-matched TB patients who had not received gastrectomy (n = 45). Treatment failure in clinical, microbiological aspects, and adverse events were analyzed. Patients who had undergone gastrectomy exhibited higher 4-month clinical failure rates, compared to non-gastrectomy patient: 4 (26.7%) vs. 1 (2.2%), P = 0.012. Gastrointestinal adverse effects were more frequent in patients with gastrectomy, compared to non-gastrectomy patients: 9 (60%) vs. 5 (11.1%), P < 0.001. In conclusion, patients treated for TB after undergoing gastrectomy are associated with higher rates of gastrointestinal adverse events and treatment failure.
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DOI
10.1620/tjem.240.281
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
구남수(Ku, Nam Su) ORCID logo https://orcid.org/0000-0002-9717-4327
김용찬(Kim, Yong Chan)
김은진(Kim, Eun Jin)
김준명(Kim, June Myung)
송제은(Song, Je Eun)
오동현(Oh, Dong Hyun)
전용덕(Jeon, Yong Duk)
정수진(Jeong, Su Jin) ORCID logo https://orcid.org/0000-0003-4025-4542
정우용(Jeong, Wooyong)
정인영(Jung, In Young)
최준용(Choi, Jun Yong) ORCID logo https://orcid.org/0000-0002-2775-3315
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/153055
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