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두경부암의 표적 치료제 저항성 기전

Other Titles
 Crosstalk Mechanisms Following Targeted Therapy in Head and Neck Cancer. 
Authors
 변형권 
Citation
 Korean Journal of Otorhinolaryngology-Head and Neck Surgery, Vol.59(3) : 181-187, 2016 
Journal Title
Korean Journal of Otorhinolaryngology-Head and Neck Surgery
ISSN
 2092-5859 
Issue Date
2016
Abstract
Head and neck squamous cell carcinoma has emerged as the sixth most commonly occurring cancer worldwide and despite advances in diagnostics and therapeutics, the treatment results and survival outcomes still remain poor, especially in advanced cancers. Due to the complexity of the local anatomic structures and the importance as vital functioning organs, the head and neck area following conventional treatment modalities such as surgery, chemotherapy, or radiotherapy often result as a devastating consequence both esthetically and functionally. In order to minimize the treatment related sequelae and at the same time maximize treatment effect, tumor-specific molecular targeted therapy has become an area under active research. Several molecular targeted agents, including the representative epidermal growth factor receptor (EGFR)-inhibitors have been developed and its therapeutic effects investigated. However, therapeutic resistance has newly risen as a main problem following targeted therapy due to a variety of resistance mechanisms. This review article looks at the major acquired resistance mechanisms following targeted agents administration including EGFR inhibitors and many others and strategies to overcome the resistance to achieve precision medicine.
Files in This Item:
T201605823.pdf Download
DOI
10.3342/kjorl-hns.2016.59.3.181
Appears in Collections:
1. College of Medicine (의과대학) > Research Institute (부설연구소) > 1. Journal Papers
Yonsei Authors
Byeon, Hyung Kwon(변형권)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/153039
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