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Feasibility of 10-Minute Delayed Hepatocyte Phase Imaging Using a 30° Flip Angle in Gd-EOB-DTPA-Enhanced Liver MRI for the Detection of Hepatocellular Carcinoma in Patients with Chronic Hepatitis or Cirrhosis

DC Field Value Language
dc.contributor.author김주희-
dc.contributor.author조은석-
dc.contributor.author유정식-
dc.contributor.author전인환-
dc.contributor.author정재준-
dc.date.accessioned2017-10-26T07:59:23Z-
dc.date.available2017-10-26T07:59:23Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152791-
dc.description.abstractOBJECTIVES: To compare 10-minute (min) delayed hepatocyte phase imaging (HPI) using a 30° flip angle (FA) (10m-FA30) and 20-min delayed HPI using a 10° FA (20m-FA10) or 30° FA (20m-FA30) in Gd-EOB-DTPA-enhanced MRI in patients with chronic hepatitis or cirrhosis, in terms of lesion-to-liver contrast-to-noise ratio (CNR) for hepatocellular carcinoma (HCC) and detection sensitivity for focal hepatic lesions (FHLs). MATERIALS AND METHODS: One hundred and four patients with 168 HCCs and 55 benign FHLs who underwent Gd-EOB-DTPA-enhanced MRI with 10m-FA30, 20m-FA10, and 20m-FA30 were enrolled. Patients were divided into two groups according to the Child-Pugh classification: group A with chronic hepatitis or Child-Pugh A cirrhosis and group B with Child-Pugh B or C cirrhosis. Lesion-to-liver CNR for HCCs was compared between 10m-FA30 and 20m-FA10 or 20m-FA30 for each group. The presence of FHLs was evaluated using a four-point scale by two independent reviewers, and the detection sensitivity was analyzed. RESULTS: In group A, the CNR for HCCs (n = 86) on 10m-FA30 (165.8 ± 99.7) was significantly higher than that on 20m-FA10 (113.4 ± 71.4) and lower than that of 20m-FA30 (210.2 ± 129.3). However, there was no significant difference in the sensitivity of FHL detection between 10m-FA30 (mean 95.0% for two reviewers) and 20m-FA10 (94.7%) or 20m-FA30 (94.7%). In group B, the CNR (54.0 ± 36.4) for HCCs (n = 57) and the sensitivity (94.2%) of FHL detection for 10m-FA30 were significantly higher than those for 20m-FA10 (41.8 ± 36.4 and 80.8%, respectively) and were not different from those for 20m-FA30 (62.7 ± 44.4 and 93.3%, respectively). CONCLUSION: The diagnostic performance of 10m-FA30 was similar to or higher than 20m-FA10 or 20m-FA30 in both groups A and B. This finding indicates that 10m-FA30 could replace 20-min delayed HPI regardless of patient liver function and reduce the delay time by 10 minutes.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherPublic Library of Science-
dc.relation.isPartOfPLOS ONE-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHCarcinoma, Hepatocellular/complications-
dc.subject.MESHCarcinoma, Hepatocellular/diagnostic imaging*-
dc.subject.MESHContrast Media/analysis*-
dc.subject.MESHFemale-
dc.subject.MESHGadolinium DTPA/analysis*-
dc.subject.MESHHepatitis, Chronic/complications*-
dc.subject.MESHHumans-
dc.subject.MESHLiver/diagnostic imaging*-
dc.subject.MESHLiver Cirrhosis/complications*-
dc.subject.MESHLiver Neoplasms/complications-
dc.subject.MESHLiver Neoplasms/diagnostic imaging*-
dc.subject.MESHMagnetic Resonance Imaging/methods*-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.titleFeasibility of 10-Minute Delayed Hepatocyte Phase Imaging Using a 30° Flip Angle in Gd-EOB-DTPA-Enhanced Liver MRI for the Detection of Hepatocellular Carcinoma in Patients with Chronic Hepatitis or Cirrhosis-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorInhwan Jeon-
dc.contributor.googleauthorEun-Suk Cho-
dc.contributor.googleauthorJoo Hee Kim-
dc.contributor.googleauthorDae Jung Kim-
dc.contributor.googleauthorJeong-Sik Yu-
dc.contributor.googleauthorJae-Joon Chung-
dc.identifier.doi10.1371/journal.pone.0167701-
dc.contributor.localIdA00951-
dc.contributor.localIdA03881-
dc.contributor.localIdA02500-
dc.contributor.localIdA05032-
dc.contributor.localIdA03712-
dc.relation.journalcodeJ02540-
dc.identifier.eissn1932-6203-
dc.identifier.pmid27936106-
dc.contributor.alternativeNameKim, Joo Hee-
dc.contributor.alternativeNameCho, Eun Suk-
dc.contributor.alternativeNameYu, Jeong Sik-
dc.contributor.alternativeNameJeon, In Hwan-
dc.contributor.alternativeNameChung, Jae Joon-
dc.contributor.affiliatedAuthorKim, Joo Hee-
dc.contributor.affiliatedAuthorCho, Eun Suk-
dc.contributor.affiliatedAuthorYu, Jeong Sik-
dc.contributor.affiliatedAuthorJeon, In Hwan-
dc.contributor.affiliatedAuthorChung, Jae Joon-
dc.citation.volume11-
dc.citation.number12-
dc.citation.startPagee0167701-
dc.identifier.bibliographicCitationPLOS ONE, Vol.11(12) : e0167701, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid40423-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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