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Feasibility of 10-Minute Delayed Hepatocyte Phase Imaging Using a 30° Flip Angle in Gd-EOB-DTPA-Enhanced Liver MRI for the Detection of Hepatocellular Carcinoma in Patients with Chronic Hepatitis or Cirrhosis
DC Field | Value | Language |
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dc.contributor.author | 김주희 | - |
dc.contributor.author | 조은석 | - |
dc.contributor.author | 유정식 | - |
dc.contributor.author | 전인환 | - |
dc.contributor.author | 정재준 | - |
dc.date.accessioned | 2017-10-26T07:59:23Z | - |
dc.date.available | 2017-10-26T07:59:23Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152791 | - |
dc.description.abstract | OBJECTIVES: To compare 10-minute (min) delayed hepatocyte phase imaging (HPI) using a 30° flip angle (FA) (10m-FA30) and 20-min delayed HPI using a 10° FA (20m-FA10) or 30° FA (20m-FA30) in Gd-EOB-DTPA-enhanced MRI in patients with chronic hepatitis or cirrhosis, in terms of lesion-to-liver contrast-to-noise ratio (CNR) for hepatocellular carcinoma (HCC) and detection sensitivity for focal hepatic lesions (FHLs). MATERIALS AND METHODS: One hundred and four patients with 168 HCCs and 55 benign FHLs who underwent Gd-EOB-DTPA-enhanced MRI with 10m-FA30, 20m-FA10, and 20m-FA30 were enrolled. Patients were divided into two groups according to the Child-Pugh classification: group A with chronic hepatitis or Child-Pugh A cirrhosis and group B with Child-Pugh B or C cirrhosis. Lesion-to-liver CNR for HCCs was compared between 10m-FA30 and 20m-FA10 or 20m-FA30 for each group. The presence of FHLs was evaluated using a four-point scale by two independent reviewers, and the detection sensitivity was analyzed. RESULTS: In group A, the CNR for HCCs (n = 86) on 10m-FA30 (165.8 ± 99.7) was significantly higher than that on 20m-FA10 (113.4 ± 71.4) and lower than that of 20m-FA30 (210.2 ± 129.3). However, there was no significant difference in the sensitivity of FHL detection between 10m-FA30 (mean 95.0% for two reviewers) and 20m-FA10 (94.7%) or 20m-FA30 (94.7%). In group B, the CNR (54.0 ± 36.4) for HCCs (n = 57) and the sensitivity (94.2%) of FHL detection for 10m-FA30 were significantly higher than those for 20m-FA10 (41.8 ± 36.4 and 80.8%, respectively) and were not different from those for 20m-FA30 (62.7 ± 44.4 and 93.3%, respectively). CONCLUSION: The diagnostic performance of 10m-FA30 was similar to or higher than 20m-FA10 or 20m-FA30 in both groups A and B. This finding indicates that 10m-FA30 could replace 20-min delayed HPI regardless of patient liver function and reduce the delay time by 10 minutes. | - |
dc.description.statementOfResponsibility | open | - |
dc.language | English | - |
dc.publisher | Public Library of Science | - |
dc.relation.isPartOf | PLOS ONE | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Adult | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Aged, 80 and over | - |
dc.subject.MESH | Carcinoma, Hepatocellular/complications | - |
dc.subject.MESH | Carcinoma, Hepatocellular/diagnostic imaging* | - |
dc.subject.MESH | Contrast Media/analysis* | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Gadolinium DTPA/analysis* | - |
dc.subject.MESH | Hepatitis, Chronic/complications* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Liver/diagnostic imaging* | - |
dc.subject.MESH | Liver Cirrhosis/complications* | - |
dc.subject.MESH | Liver Neoplasms/complications | - |
dc.subject.MESH | Liver Neoplasms/diagnostic imaging* | - |
dc.subject.MESH | Magnetic Resonance Imaging/methods* | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.title | Feasibility of 10-Minute Delayed Hepatocyte Phase Imaging Using a 30° Flip Angle in Gd-EOB-DTPA-Enhanced Liver MRI for the Detection of Hepatocellular Carcinoma in Patients with Chronic Hepatitis or Cirrhosis | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiology | - |
dc.contributor.googleauthor | Inhwan Jeon | - |
dc.contributor.googleauthor | Eun-Suk Cho | - |
dc.contributor.googleauthor | Joo Hee Kim | - |
dc.contributor.googleauthor | Dae Jung Kim | - |
dc.contributor.googleauthor | Jeong-Sik Yu | - |
dc.contributor.googleauthor | Jae-Joon Chung | - |
dc.identifier.doi | 10.1371/journal.pone.0167701 | - |
dc.contributor.localId | A00951 | - |
dc.contributor.localId | A03881 | - |
dc.contributor.localId | A02500 | - |
dc.contributor.localId | A05032 | - |
dc.contributor.localId | A03712 | - |
dc.relation.journalcode | J02540 | - |
dc.identifier.eissn | 1932-6203 | - |
dc.identifier.pmid | 27936106 | - |
dc.contributor.alternativeName | Kim, Joo Hee | - |
dc.contributor.alternativeName | Cho, Eun Suk | - |
dc.contributor.alternativeName | Yu, Jeong Sik | - |
dc.contributor.alternativeName | Jeon, In Hwan | - |
dc.contributor.alternativeName | Chung, Jae Joon | - |
dc.contributor.affiliatedAuthor | Kim, Joo Hee | - |
dc.contributor.affiliatedAuthor | Cho, Eun Suk | - |
dc.contributor.affiliatedAuthor | Yu, Jeong Sik | - |
dc.contributor.affiliatedAuthor | Jeon, In Hwan | - |
dc.contributor.affiliatedAuthor | Chung, Jae Joon | - |
dc.citation.volume | 11 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | e0167701 | - |
dc.identifier.bibliographicCitation | PLOS ONE, Vol.11(12) : e0167701, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 40423 | - |
dc.type.rims | ART | - |
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