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Bendamustine in heavily pre-treated multiple myeloma patients: Results of a retrospective analysis from the Korean Multiple Myeloma Working Party

Authors
 Seok Jin Kim  ;  Soo-Mee Bang  ;  Yoon Seok Choi  ;  Deog-Yeon Jo  ;  Jin Seok Kim  ;  Hyewon Lee  ;  Hyeon Seok Eom  ;  Dok Hyun Yoon  ;  Cheolwon Suh  ;  Je-Jung Lee  ;  Junshik Hong  ;  Jae Hoon Lee  ;  Youngil Koh  ;  Kihyun Kim  ;  Sung-Soo Yoon  ;  Chang-Ki Min 
Citation
 BLOOD RESEARCH, Vol.51(3) : 193-199, 2016 
Journal Title
 BLOOD RESEARCH 
ISSN
 2287-979X 
Issue Date
2016
Keywords
Bendamustine ; Myeloma ; Response ; Survival ; Toxicity
Abstract
BACKGROUND: Bendamustine may be a potential treatment option for patients with myeloma, but little is known about the utility of bendamustine as a salvage treatment, especially in Asian patients. METHODS: We performed a multicenter retrospective study of patients with relapsed or refractory myeloma who received bendamustine and prednisone. RESULTS: The records of 65 heavily pre-treated patients, who had undergone bortezomib and lenalidomide treatment (median number of previous treatments: 5), were analyzed. The median time from diagnosis to bendamustine treatment was 3.8 years, and the median patient age was 63 years (range, 38?77 yr). The responses to the last treatment before bendamustine were refractory disease (N=52, 80%) or disease progression from partial response (N=13, 20%). Twenty-three patients responded to the treatment, with an overall response rate of 35% (23/65), and the median number of bendamustine treatment cycles was two (range, 1?5 cycles). The median overall survival after bendamustine treatment was 5.5 months and the overall survival rate in responders to bendamustine was significantly better than that in non-responders (P=0.036). CONCLUSION: Bendamustine may be a potential salvage treatment to extend survival in a select group of heavily pre-treated patients with relapsed or refractory myeloma.
Files in This Item:
T201605350.pdf Download
DOI
10.5045/br.2016.51.3.193
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Jin Seok(김진석) ORCID logo https://orcid.org/0000-0001-8986-8436
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152785
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