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Pulmonary fissure development is a prognostic factor for patients with resected stage I lung adenocarcinoma

Authors
 Seokkee Lee  ;  Jin Gu Lee  ;  Chang Young Lee  ;  Dae Joon Kim  ;  Kyung Young Chung 
Citation
 Journal of Surgical Oncology, Vol.114(7) : 848-852, 2016 
Journal Title
 Journal of Surgical Oncology 
ISSN
 0022-4790 
Issue Date
2016
MeSH
Adenocarcinoma/mortality ; Adenocarcinoma/pathology ; Adenocarcinoma/surgery* ; Adult ; Aged ; Carcinoma, Non-Small-Cell Lung/mortality ; Carcinoma, Non-Small-Cell Lung/pathology ; Carcinoma, Non-Small-Cell Lung/surgery* ; Female ; Follow-Up Studies ; Humans ; Lung/pathology* ; Lung/surgery ; Lung Neoplasms/mortality ; Lung Neoplasms/pathology ; Lung Neoplasms/surgery* ; Male ; Middle Aged ; Neoplasm Staging ; Pneumonectomy*/methods ; Prognosis ; Retrospective Studies ; Severity of Illness Index ; Survival Analysis ; Thoracic Surgery, Video-Assisted
Keywords
adenocarcinoma ; non-small cell lung cancer ; pleura ; prognosis
Abstract
BACKGROUND: Pulmonary fissure differs among patients, but the relationship between pulmonary fissure development and survival in patients with resected lung adenocarcinoma has not been evaluated. In this study, we analyzed the effect of fissure development on prognosis in patients with stage I lung adenocarcinoma. METHODS: From January 2009 to December 2012, data, including pulmonary fissure development, were collected prospectively for all lung cancer, and this was a retrospective study of prospectively collected data. In total, 297 patients who had undergone a lobectomy and had pathologic stage I adenocarcinoma were analyzed. Patients were categorized into two groups based on fissure sum average (FSA) fissure development scores. Group A patients ranged from complete to 30% incomplete (0?≤?FSA?≤?1) while in Group B patients development was more than 30% incomplete (1?<?FSA?≤?3). RESULTS: In univariate analysis, Group B had poorer overall 5 year survival than did Group A (83.1% vs. 96.5%, P?=?0.015). Multivariate analysis revealed that the level of fissure development was a significant prognostic factor for overall survival (HR?=?3.905, CI?=?1.168-13.057, P?=?0.027). CONCLUSIONS: The overall survival of patients with resected stage I adenocarcinoma was adversely affected by incomplete fissure development.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/jso.24438/abstract
DOI
10.1002/jso.24438
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Thoracic and Cardiovascular Surgery (흉부외과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dae Joon(김대준)
Lee, Jin Gu(이진구)
Lee, Chang Young(이창영)
Chung, Kyung Young(정경영)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152782
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