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Recursive partition analysis of peritoneal and systemic recurrence in patients with gastric cancer who underwent D2 gastrectomy: Implications for neoadjuvant therapy consideration

DC FieldValueLanguage
dc.contributor.author금기창-
dc.contributor.author금웅섭-
dc.contributor.author김효송-
dc.contributor.author노성훈-
dc.contributor.author라선영-
dc.contributor.author이용찬-
dc.contributor.author임준석-
dc.contributor.author장지석-
dc.contributor.author형우진-
dc.date.accessioned2017-10-26T07:58:31Z-
dc.date.available2017-10-26T07:58:31Z-
dc.date.issued2016-
dc.identifier.issn0022-4790-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152762-
dc.description.abstractBACKGROUND AND OBJECTIVES: To classify patients with nonmetastatic advanced gastric cancer who underwent D2-gastrectomy into prognostic groups based on peritoneal and systemic recurrence risks. METHODS: Between 2004 and 2007, 1,090 patients with T3-4 or N+ gastric cancer were identified from our registry. Recurrence rates were estimated using a competing-risk analysis. Different prognostic groups were defined using recursive partitioning analysis (RPA). RESULTS: Median follow-up was 7 years. In the RPA-model for peritoneal recurrence risk, the initial node was split by T stage, indicating that differences between patients with T1-3 and T4 cancer were the greatest. The 5-year peritoneal recurrence rates for patients with T4 (n?=?627) and T1-3 (n?=?463) disease were 34.3% and 9.1%, respectively. N stage and neural invasion had an additive impact on high-risk patients. The RPA model for systemic relapse incorporated N stage alone and gave two terminal nodes: N0-2 (n?=?721) and N3 (n?=?369). The 5-year cumulative incidences were 7.7% and 24.5%, respectively. CONCLUSIONS: We proposed risk stratification models of peritoneal and systemic recurrence in patients undergoing D2-gastrectomy. This classification could be used for stratification protocols in future studies evaluating adjuvant therapies such as preoperative chemoradiotherapy.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherWiley-Liss-
dc.relation.isPartOfJournal of Surgical Oncology-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdenocarcinoma/diagnosis-
dc.subject.MESHAdenocarcinoma/prevention & control-
dc.subject.MESHAdenocarcinoma/secondary*-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHAged, 80 and over-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHGastrectomy*/methods-
dc.subject.MESHHumans-
dc.subject.MESHLymph Node Excision-
dc.subject.MESHLymphatic Metastasis-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHNeoadjuvant Therapy-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPeritoneal Neoplasms/diagnosis-
dc.subject.MESHPeritoneal Neoplasms/prevention & control-
dc.subject.MESHPeritoneal Neoplasms/secondary*-
dc.subject.MESHPrognosis-
dc.subject.MESHRetrospective Studies-
dc.subject.MESHStomach Neoplasms/pathology*-
dc.subject.MESHStomach Neoplasms/surgery*-
dc.subject.MESHStomach Neoplasms/therapy-
dc.titleRecursive partition analysis of peritoneal and systemic recurrence in patients with gastric cancer who underwent D2 gastrectomy: Implications for neoadjuvant therapy consideration-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiation Oncology-
dc.contributor.googleauthorJee Suk Chang-
dc.contributor.googleauthorKyung Hwan Kim-
dc.contributor.googleauthorKi Chang Keum-
dc.contributor.googleauthorSung Hoon Noh-
dc.contributor.googleauthorJoon Seok Lim-
dc.contributor.googleauthorHyo Song Kim-
dc.contributor.googleauthorSun Young Rha-
dc.contributor.googleauthorYong Chan Lee-
dc.contributor.googleauthorWoo Jin Hyung-
dc.contributor.googleauthorWoong Sub Koom-
dc.identifier.doi10.1002/jso.24405-
dc.contributor.localIdA00273-
dc.contributor.localIdA01202-
dc.contributor.localIdA01281-
dc.contributor.localIdA01316-
dc.contributor.localIdA02988-
dc.contributor.localIdA03408-
dc.contributor.localIdA00272-
dc.contributor.localIdA04658-
dc.contributor.localIdA04382-
dc.relation.journalcodeJ01762-
dc.identifier.pmid27511744-
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/jso.24405/abstract-
dc.subject.keywordgastrectomy-
dc.subject.keywordgastric cancer-
dc.subject.keywordrecurrence-
dc.subject.keywordrecursive partition analysis-
dc.subject.keywordsurvival-
dc.contributor.alternativeNameKeum, Ki Chang-
dc.contributor.alternativeNameKoom, Woong Sub-
dc.contributor.alternativeNameKim, Hyo Song-
dc.contributor.alternativeNameNoh, Sung Hoon-
dc.contributor.alternativeNameRha, Sun Young-
dc.contributor.alternativeNameLee, Yong Chan-
dc.contributor.alternativeNameLim, Joon Seok-
dc.contributor.alternativeNameChang, Jee Suk Paul-
dc.contributor.alternativeNameHyung, Woo Jin-
dc.contributor.affiliatedAuthorKoom, Woong Sub-
dc.contributor.affiliatedAuthorKim, Hyo Song-
dc.contributor.affiliatedAuthorNoh, Sung Hoon-
dc.contributor.affiliatedAuthorRha, Sun Young-
dc.contributor.affiliatedAuthorLee, Yong Chan-
dc.contributor.affiliatedAuthorLim, Joon Seok-
dc.contributor.affiliatedAuthorKeum, Ki Chang-
dc.contributor.affiliatedAuthorChang, Jee Suk Paul-
dc.contributor.affiliatedAuthorHyung, Woo Jin-
dc.citation.volume114-
dc.citation.number7-
dc.citation.startPage859-
dc.citation.endPage864-
dc.identifier.bibliographicCitationJournal of Surgical Oncology, Vol.114(7) : 859-864, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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