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소아에서 혈청 25-hydroxyvitamin D와 알레르기비염의 연관성

Other Titles
 Association between the serum 25-hydroxyvitamin D level and allergic rhinitis in Korean children 
Authors
 윤서희  ;  김정윤  ;  김윤희  ;  박영아  ;  설인숙  ;  김민정  ;  김경원  ;  손명현  ;  김규언 
Citation
 Allergy Asthma & Respiratory Disease, Vol.4(6) : 423-428, 2016 
Journal Title
 Allergy Asthma & Respiratory Disease 
ISSN
 2288-0402 
Issue Date
2016
Abstract
Purpose: Vitamin D is known to play an important role in the regulation of the immune system and in the prevention of allergic disease. Herein, we examined the association between vitamin D and allergic rhinitis (AR) in children. Methods: A total of 72 aeroallergen-proven AR and 57 healthy control subjects who visited Severance Children’s Hospital between 2012 and 2014 were evaluated. The mean serum 25-hydroxyvitamin D (25(OH)D) level was measured in all subjects to evaluate their vitamin D status. Results: The mean serum 25(OH)D levels was significantly lower in patients with AR than in controls (19.5±6.4 ng/mL vs. 22.3±5.8 ng/mL, P=0.013). The incidence of AR is higher in the 25(OH)D-insufficient group (15?20 ng/mL) and in the 25(OH)D-deficient group (≤15 ng/mL) compared with the 25(OH)D-sufficient group (>20 ng/mL) (40.3% vs. 84.4% vs. 22.2%, P<0.001). There was no significant difference in the serum 25(OH)D level between subgroups with mild and moderate-to-severe AR symptoms (19.8±6.5 vs. 19.0±6.3, P=0.596). After adjusting for confounding factors, the lower serum vitamin D level groups had increased odds of AR compared with the 25(OH)D-sufficient group (odds ration [95% confidence interval]; 3.67 [1.29?10.38] in the 25(OH)D-insufficient group; P=0.014 and 6.04 [1.49?24.51] in the 25(OH)D-deficient group; P=0.012). Conclusion: The serum vitamin D levels were significantly lower in children with AR compared with healthy controls. Therefore, lower serum level of 25(OH)D may be associated with the development of AR.
DOI
10.4168/aard.2016.4.6.423
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
김경원(Kim, Kyung Won) ORCID logo https://orcid.org/0000-0003-4529-6135
김규언(Kim, Kyu Earn)
김윤희(Kim, Yoon Hee) ORCID logo https://orcid.org/0000-0002-2149-8501
김정윤(Kim, Jung Yoon)
박영아(Park, Young A)
설인숙(Sol, In Suk) ORCID logo https://orcid.org/0000-0003-2470-9682
손명현(Sohn, Myung Hyun) ORCID logo https://orcid.org/0000-0002-2478-487X
윤서희(Yoon, Seo Hee) ORCID logo https://orcid.org/0000-0002-8361-9815
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152746
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