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Long-Term Antibacterial Performance and Bioactivity of Plasma-Engineered Ag-NPs/TiO2 Nanotubes for Bio-Implants

Authors
 Uhm, Soo-Hyuk  ;  Kwon, Jae-Sung  ;  Song, Doo-Hoon  ;  Lee, Eun-Jung  ;  Jeong, Won-Seok  ;  OH, Seunghan  ;  Kim, Kyoung-Nam  ;  Choi, Eun Ha  ;  Kim, Kwang-Mahn 
Citation
 JOURNAL OF BIOMEDICAL NANOTECHNOLOGY, Vol.12(10) : 1890-1906, 2016 
Journal Title
 JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 
ISSN
 1550-7033 
Issue Date
2016
Abstract
We prepared TiO2 nanotubes (NT) on commercially pure titanium (cp-Ti) substrate by plasma electrolyte oxidation and adapted magnetron sputtering for incorporation of Ag-nanoparticles (Ag-NPs) onto the nanotubes (Ag-NPs/TiO2 nanotube). Power input to the Ag target per unit time was varied (5, 10, 15 W/cm2) to fabricate different shapes of Agnanoparticles onto the nanotubes while net energy input was fixed by maintaining a constant total sputter time (30, 15, 10 s, respectively). For investigation of experimental samples' characteristics, FE-SEM, TEM, EDS, XRD, XPS, SPM analysis and contact angles measurement was carried out. Through these characterization, plasma engineered Ag-NPs was successfully formed on/in the entire nanotube structure. In terms of antibacterial ability, plasma engineered Ag-NPs/TiO2 nanotubes samples significantly reduced S. aureus colony numbers compared with control. Also, simulated body fluid immersion tests with hydroxyapatite showed ion precipitation onto the surface of all experimental groups, confirmed by XRD and EDS analysis. However, plasma engineered Ag-NPs/TiO2 nanotubes groups were not cytotoxic. Furthermore, MC3T3-E1 cells were cultured on Ag-NPs/TiO2 nanotubes groups to evaluate the effect of nanostructured surface on cell functionality such as a cell proliferation and ALP activity. Ag-NPs/TiO2 nanotubes have both biocompatible and antibacterial characteristics.
Full Text
http://www.ingentaconnect.com/contentone/asp/jbn/2016/00000012/00000010/art00005
DOI
10.1166/jbn.2016.2310
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Dental Biomaterials and Bioengineering (치과생체재료공학교실) > 1. Journal Papers
Yonsei Authors
Kwon, Jae-Sung(권재성) ORCID logo https://orcid.org/0000-0001-9803-7730
Kim, Kyoung Nam(김경남)
Kim, Kwang Mahn(김광만) ORCID logo https://orcid.org/0000-0002-5235-0294
Song, Doo Hoon(송두훈)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152739
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