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Mycobacterium abscessus D-alanyl-D-alanine dipeptidase induces the maturation of dendritic cells and promotes Th1-biased immunity

Authors
 Seung Jun Lee  ;  Jong-Hwa Jang  ;  Gun Young Yoon  ;  Da Rae Kang  ;  Hee Jo Park  ;  Sung Jae Shin  ;  Hee Dong Han  ;  Tae Heung Kang  ;  Won Sun Park  ;  Young Kyung Yoon  ;  Byoung Yul Soh  ;  In Duk Jung  ;  Yeong-Min Park 
Citation
 BMB REPORTS, Vol.49(10) : 554-559, 2016 
Journal Title
 BMB REPORTS 
ISSN
 1976-6696 
Issue Date
2016
Abstract
Mycobacterium abscessus, a member of the group of non-tuberculous mycobacteria, has been identified as an emerging pulmonary pathogen in humans. However, little is known about the protective immune response of antigenpresenting cells, such as dendritic cells (DCs), which guard against M. abscessus infection. The M. abscessus gene MAB1843 encodes D-alanyl-D-alanine dipeptidase, which catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide. We investigated whether MAB1843 is able to interact with DCs to enhance the effectiveness of the host's immune response. MAB1843 was found to induce DC maturation via toll-like receptor 4 and its downstream signaling pathways, such as the mitogen-activated protein kinase and nuclear factor kappa B pathways. In addition, MAB1843-treated DCs stimulated the proliferation of T cells and promoted Th1 polarization. Our results indicate that MAB1843 could potentially regulate the immune response to M. abscessus, making it important in the development of an effective vaccine against this mycobacterium.
Files in This Item:
T201605226.pdf Download
DOI
10.5483/BMBRep.2016.49.10.080
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Microbiology (미생물학교실) > 1. Journal Papers
Yonsei Authors
Shin, Sung Jae(신성재) ORCID logo https://orcid.org/0000-0003-0854-4582
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152710
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