Cited 11 times in
Magnetic Nanovector Enabling miRNA-34a Delivery for CD44 Suppression with Concurrent MR Imaging
DC Field | Value | Language |
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dc.contributor.author | 손혜영 | - |
dc.contributor.author | 허용민 | - |
dc.date.accessioned | 2017-10-26T07:55:56Z | - |
dc.date.available | 2017-10-26T07:55:56Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1533-4880 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152703 | - |
dc.description.abstract | We report the development of a microRNA (miRNA)-based theragnostic system that can facilitate simple therapeutic miRNA-34a delivery and visualization by high-resolution magnetic resonance (MR) imaging. Magnetic nanovectors were formed by directly attaching miRNA-34a to the surface of magnetic nanoparticles (MNPs), modified nitrosonium tetrafluoroborate (NOBF4) and subsequently introduced polyethylene glycol (PEG) molecules for high stability in an aqueous phase. The miRNA-34a?conjugated magnetic nanovectors showed therapeutic effects, inhibiting cellular migration and invasion through CD44 gene suppression; they also exhibited a strong MR signal. These results demonstrate that magnetic nanovectors have potential as theragnostic nanosystems for miRNA-based cancer therapy. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | American Scientific Publishers | - |
dc.relation.isPartOf | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Magnetic Nanovector Enabling miRNA-34a Delivery for CD44 Suppression with Concurrent MR Imaging | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Life Science | - |
dc.contributor.googleauthor | Lee, Hwunjae | - |
dc.contributor.googleauthor | Kim, Hyun-Ouk | - |
dc.contributor.googleauthor | Son, Hye-Young | - |
dc.contributor.googleauthor | Lee, Sang-Bock | - |
dc.contributor.googleauthor | Jang, Eunji | - |
dc.contributor.googleauthor | Kang, Byunghoon | - |
dc.contributor.googleauthor | Haam, Seungjoo | - |
dc.contributor.googleauthor | Lim, Eun-Kyung | - |
dc.contributor.googleauthor | Huh, Yong-Min | - |
dc.identifier.doi | 10.1166/jnn.2016.13797 | - |
dc.contributor.localId | A04359 | - |
dc.contributor.localId | A04589 | - |
dc.relation.journalcode | J01615 | - |
dc.identifier.eissn | 1533-4899 | - |
dc.identifier.url | http://www.ingentaconnect.com/contentone/asp/jnn/2016/00000016/00000012/art00138 | - |
dc.contributor.alternativeName | Son, Hye Yeong | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Son, Hye Yeong | - |
dc.citation.volume | 16 | - |
dc.citation.number | 12 | - |
dc.citation.startPage | 12939 | - |
dc.citation.endPage | 12946 | - |
dc.identifier.bibliographicCitation | JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY, Vol.16(12) : 12939-12946, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 39712 | - |
dc.type.rims | ART | - |
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