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Mutation profiling of 19 candidate genes in acute myeloid leukemia suggests significance of DNMT3A mutations

Authors
 Sang-Yong Shin  ;  Seung-Tae Lee  ;  Hee-Jin Kim  ;  Eun Hae Cho  ;  Jong-Won Kim  ;  Silvia Park  ;  Chul Won Jung  ;  Sun-Hee Kim 
Citation
 ONCOTARGET , Vol.7(34) : 54825-54837, 2016 
Journal Title
 ONCOTARGET 
Issue Date
2016
Abstract
We selected 19 significantly-mutated genes in AMLs, including FLT3, DNMT3A, NPM1, TET2, RUNX1, CEBPA, WT1, IDH1, IDH2, NRAS, ASXL1, SETD2, PTPN11, TP53, KIT, JAK2, KRAS, BRAF and CBL, and performed massively parallel sequencing for 114 patients with acute myeloid leukemias, mainly including those with normal karyotypes (CN-AML). More than 80% of patients had at least one mutation in the genes tested. DNMT3A mutation was significantly associated with adverse outcome in addition to conventional risk stratification such as the European LeukemiaNet (ELN) classification. We observed clinical usefulness of mutation testing on multiple target genes and the association with disease subgroups, clinical features and prognosis in AMLs.
Files in This Item:
T201604970.pdf Download
DOI
10.18632/oncotarget.10240
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers
Yonsei Authors
Lee, Seung-Tae(이승태) ORCID logo https://orcid.org/0000-0003-1047-1415
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152695
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