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Mutation profiling of 19 candidate genes in acute myeloid leukemia suggests significance of DNMT3A mutations

DC FieldValueLanguage
dc.contributor.author이승태-
dc.date.accessioned2017-10-26T07:55:18Z-
dc.date.available2017-10-26T07:55:18Z-
dc.date.issued2016-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152695-
dc.description.abstractWe selected 19 significantly-mutated genes in AMLs, including FLT3, DNMT3A, NPM1, TET2, RUNX1, CEBPA, WT1, IDH1, IDH2, NRAS, ASXL1, SETD2, PTPN11, TP53, KIT, JAK2, KRAS, BRAF and CBL, and performed massively parallel sequencing for 114 patients with acute myeloid leukemias, mainly including those with normal karyotypes (CN-AML). More than 80% of patients had at least one mutation in the genes tested. DNMT3A mutation was significantly associated with adverse outcome in addition to conventional risk stratification such as the European LeukemiaNet (ELN) classification. We observed clinical usefulness of mutation testing on multiple target genes and the association with disease subgroups, clinical features and prognosis in AMLs.-
dc.description.statementOfResponsibilityopen-
dc.languageEnglish-
dc.publisherImpact Journals-
dc.relation.isPartOfONCOTARGET-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleMutation profiling of 19 candidate genes in acute myeloid leukemia suggests significance of DNMT3A mutations-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Laboratory Medicine-
dc.contributor.googleauthorSang-Yong Shin-
dc.contributor.googleauthorSeung-Tae Lee-
dc.contributor.googleauthorHee-Jin Kim-
dc.contributor.googleauthorEun Hae Cho-
dc.contributor.googleauthorJong-Won Kim-
dc.contributor.googleauthorSilvia Park-
dc.contributor.googleauthorChul Won Jung-
dc.contributor.googleauthorSun-Hee Kim-
dc.identifier.doi10.18632/oncotarget.10240-
dc.contributor.localIdA04627-
dc.relation.journalcodeJ02421-
dc.identifier.eissn1949-2553-
dc.identifier.pmid27359055-
dc.contributor.alternativeNameLee, Seung-Tae-
dc.contributor.affiliatedAuthorLee, Seung-Tae-
dc.citation.volume7-
dc.citation.number34-
dc.citation.startPage54825-
dc.citation.endPage54837-
dc.identifier.bibliographicCitationONCOTARGET , Vol.7(34) : 54825-54837, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Laboratory Medicine (진단검사의학교실) > 1. Journal Papers

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