160 148

Cited 1 times in

Effect of Areca Nut on Helicobacter pylori-Induced Gastric Diseases in Mice

Authors
 Jinwook Lee  ;  Niluka D. Gunawardhana  ;  Sungil Jang  ;  Yun Hui Choi  ;  Rasika P. Illeperuma  ;  Aeryun Kim  ;  Hanfu Su  ;  Youngmin A. Hong  ;  Ji-Hye Kim  ;  Jinmoon Kim  ;  Da-Woon Jung  ;  In-Ho Cha  ;  Eun-Jung Bak  ;  Jeong-Heon Cha 
Citation
 JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY, Vol.26(10) : 1817-1823, 2016 
Journal Title
 JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY 
ISSN
 1017-7825 
Issue Date
2016
Abstract
Areca nut (AN) chewing is a habit in many countries in Central, Southern, and Southeast Asia. It is strongly associated with the occurrence of oral, pharyngeal, and esophageal cancer as well as systemic inflammation. However, the association between AN intake and the development of gastric lesions has not yet been identified. The aim of this study was to investigate the effect of AN on gastric diseases using a mouse model for Helicobacter pylori infection. We studied four groups of mice: those fed a normal diet (ND), those fed a diet containing 2.5% AN (AD), those fed ND and infected with H. pylori PMSS1 strain (ND/HP), and those fed AD and infected with H. pylori PMSS1 strain (AD/HP). Food intake and body weight were monitored weekly during the experiments. At 10 weeks, the mice were sacrificed, and the stomach weight, H. pylori colonization, and gastric inflammation were evaluated. The stomach weight had increased significantly in the ND/HP and AD/HP groups along with increases in H. pylori colonization; however, there was no significant difference between these two groups with respect to stomach weight and colonization. On histological grading, mononuclear cell infiltration was severer in the AD/HP group than in the ND/HP group. These data suggest that chronic gastric inflammation was aggravated by AN treatment in the mice with H. pylori-induced gastric lesions. Furthermore, as previously suggested, this animal model is useful to determine the effect of potential carcinogens on gastric lesions induced by H. pylori infection.
Files in This Item:
T201604945.pdf Download
DOI
10.4014/jmb.1606.06043
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Jang, Sungil(장성일) ORCID logo https://orcid.org/0000-0001-6144-6899
Cha, In Ho(차인호) ORCID logo https://orcid.org/0000-0001-8259-2190
Cha, Jung Heon(차정헌) ORCID logo https://orcid.org/0000-0002-9385-2653
Hong, Youngmin A.(홍영민)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152681
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse