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Are sleep disorders associated with increased mortality in asthma patients?

Authors
 Kyu-Tae Han  ;  Hong-Chul Bae  ;  Sang Gyu Lee  ;  Seung Ju Kim  ;  Woorim Kim  ;  Hyo Jung Lee  ;  Yeong Jun Ju  ;  Eun-Cheol Park 
Citation
 BMC Pulmonary Medicine, Vol.16(1) : 154, 2016 
Journal Title
 BMC Pulmonary Medicine 
Issue Date
2016
Abstract
BACKGROUND: South Korea has experienced problems regarding poor management of symptoms of asthma patients and remarkable increases in sleep disorders. However, few studies have investigated these issues. We examined the relationship between sleep disorders and mortality in asthma patients to suggest effective alternatives from a novel perspective. METHODS: We used data from the National Health Insurance Service (NHIS) National Sample Cohort 2004-2013, which included medical claims filed for 186,491 patients who were newly diagnosed with asthma during the study period. We performed survival analyses using a Cox proportional hazards model with time-dependent covariates to examine the relationship between sleep disorders and mortality in asthma patients. RESULTS: There were 5179 (2.78%) patients who died during the study period. Sleep disorders in patients previously diagnosed with asthma were associated with a higher risk of mortality (hazard ratio [HR]: 1.451, 95% confidence interval [CI]: 1.253-1.681). In addition, significant interaction was found between sleep disorders and Charlson comorbidity index. CONCLUSIONS: Our findings suggest that an increased prevalence of sleep disorders in asthma patients increases the risk of mortality. Considering the worsening status of asthma management and the rapid growth of sleep disorders in South Korea, clinicians and health policymakers should work to develop interventions to address these issues.
Files in This Item:
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DOI
10.1186/s12890-016-0313-2
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Park, Eun-Cheol(박은철) ORCID logo https://orcid.org/0000-0002-2306-5398
Lee, Sang Gyu(이상규) ORCID logo https://orcid.org/0000-0003-4847-2421
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152662
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