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Serum 25-Hydroxyvitamin D Concentration Is Independently Inversely Associated with Insulin Resistance in the Healthy, Non-Obese Korean Population

Authors
 So Young Ock  ;  Kyoung Hwa Ha  ;  Bu Kyung Kim  ;  Hyeon Chang Kim  ;  Jee-Seon Shim  ;  Myung Ha Lee  ;  Young Me Yoon  ;  Dae Jung Kim 
Citation
 DIABETES & METABOLISM JOURNAL, Vol.40(5) : 367-375, 2016 
Journal Title
 DIABETES & METABOLISM JOURNAL 
ISSN
 2233-6079 
Issue Date
2016
Abstract
BACKGROUND: We evaluated the associations between 25-hydroxyvitamin D (25(OH)D) concentrations in serum and insulin resistance in the healthy Korean population. METHODS: We conducted this cross-sectional analysis in 1,807 healthy Korean people (628 men and 1,179 women) aged 30 to 64 years in the Cardiovascular and Metabolic Disease Etiologic Research Center study. All participants were assessed for 25(OH)D, fasting glucose, and insulin levels, and completed a health examination and lifestyle questionnaire according to standard procedures. Insulin resistance was defined as the homeostasis model assessment insulin resistance higher than the 75 percentile. RESULTS: Compared to those in the highest tertile (≥14.3 ng/mL), the odds ratio (OR) for insulin resistance was 1.37 (95% confidence interval [CI], 1.01 to 1.86) for the 1st tertile (<9.7 ng/mL) and 1.19 (95% CI, 0.08 to 1.62) for the 2nd tertile (9.7 to 14.3 ng/mL) after adjusting for age, gender, waist circumference, alcohol consumption, smoking status, physical exercise, season, and cohort. After stratification of the subjects by adiposity, these associations remained only in non-obese subjects (lowest tertile vs. highest tertile, multivariable OR, 1.64; 95% CI, 1.05 to 2.56). CONCLUSION: Serum 25(OH)D has an independent inverse association with insulin resistance in the healthy, non-obese Korean population, even among people with vitamin D insufficiency.
Files in This Item:
T201604823.pdf Download
DOI
10.4093/dmj.2016.40.5.367
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine and Public Health (예방의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Shim, Jee Seon(심지선) ORCID logo https://orcid.org/0000-0002-8671-3153
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152588
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