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Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model

Authors
 Hyun Ho Jung  ;  Jaewoo Shin  ;  Jinhyung Kim  ;  Seung-Hee Ahn  ;  Sung Eun Lee  ;  Chin Su Koh  ;  Jae Sung Cho  ;  Chanho Kong  ;  Hyung-Cheul Shin  ;  Sung June Kim  ;  Jin Woo Chang 
Citation
 NEURAL PLASTICITY, Vol.2016 : 3898924, 2016 
Journal Title
NEURAL PLASTICITY
ISSN
 2090-5904 
Issue Date
2016
MeSH
Animals ; Cerebral Cortex/physiopathology* ; Male ; Motor Cortex/physiopathology* ; Neuralgia/physiopathology* ; Pain Measurement* ; Pain Threshold/physiology* ; Proto-Oncogene Proteins c-fos/metabolism ; Rats, Sprague-Dawley ; Thalamus/physiopathology
Abstract
It is well known that the insular cortex is involved in the processing of painful input. The aim of this study was to evaluate the pain modulation role of the insular cortex during motor cortex stimulation (MCS). After inducing neuropathic pain (NP) rat models by the spared nerve injury method, we made a lesion on the rostral agranular insular cortex (RAIC) unilaterally and compared behaviorally determined pain threshold and latency in 2 groups: Group A (NP + MCS; n = 7) and Group B (NP + RAIC lesion + MCS; n = 7). Also, we simultaneously recorded neuronal activity (NP; n = 9) in the thalamus of the ventral posterolateral nucleus and RAIC to evaluate electrophysiological changes from MCS. The pain threshold and tolerance latency increased in Group A with "MCS on" and in Group B with or without "MCS on." Moreover, its increase in Group B with "MCS on" was more than that of Group B without MCS or of Group A, suggesting that MCS and RAIC lesioning are involved in pain modulation. Compared with the "MCS off" condition, the "MCS on" induced significant threshold changes in an electrophysiological study. Our data suggest that the RAIC has its own pain modulation effect, which is influenced by MCS.
Files in This Item:
T201604360.pdf Download
DOI
10.1155/2016/3898924
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers
Yonsei Authors
Shin, Jaewoo(신재우) ORCID logo https://orcid.org/0000-0002-6335-1292
Chang, Jin Woo(장진우) ORCID logo https://orcid.org/0000-0002-2717-0101
Jung, Hyun Ho(정현호)
Cho, Jae Sung(조재성)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152404
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