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Rostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model

DC Field Value Language
dc.contributor.author장진우-
dc.contributor.author정현호-
dc.contributor.author조재성-
dc.contributor.author신재우-
dc.contributor.author신재우-
dc.date.accessioned2017-10-26T07:42:24Z-
dc.date.available2017-10-26T07:42:24Z-
dc.date.issued2016-
dc.identifier.issn2090-5904-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152404-
dc.description.abstractIt is well known that the insular cortex is involved in the processing of painful input. The aim of this study was to evaluate the pain modulation role of the insular cortex during motor cortex stimulation (MCS). After inducing neuropathic pain (NP) rat models by the spared nerve injury method, we made a lesion on the rostral agranular insular cortex (RAIC) unilaterally and compared behaviorally determined pain threshold and latency in 2 groups: Group A (NP + MCS; n = 7) and Group B (NP + RAIC lesion + MCS; n = 7). Also, we simultaneously recorded neuronal activity (NP; n = 9) in the thalamus of the ventral posterolateral nucleus and RAIC to evaluate electrophysiological changes from MCS. The pain threshold and tolerance latency increased in Group A with "MCS on" and in Group B with or without "MCS on." Moreover, its increase in Group B with "MCS on" was more than that of Group B without MCS or of Group A, suggesting that MCS and RAIC lesioning are involved in pain modulation. Compared with the "MCS off" condition, the "MCS on" induced significant threshold changes in an electrophysiological study. Our data suggest that the RAIC has its own pain modulation effect, which is influenced by MCS.-
dc.description.statementOfResponsibilityopen-
dc.formatapplication/octet-stream-
dc.languageEnglish-
dc.publisherHindawi Publishing Corporation-
dc.relation.isPartOfNEURAL PLASTICITY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAnimals-
dc.subject.MESHCerebral Cortex/physiopathology*-
dc.subject.MESHMale-
dc.subject.MESHMotor Cortex/physiopathology*-
dc.subject.MESHNeuralgia/physiopathology*-
dc.subject.MESHPain Measurement*-
dc.subject.MESHPain Threshold/physiology*-
dc.subject.MESHProto-Oncogene Proteins c-fos/metabolism-
dc.subject.MESHRats, Sprague-Dawley-
dc.subject.MESHThalamus/physiopathology-
dc.titleRostral Agranular Insular Cortex Lesion with Motor Cortex Stimulation Enhances Pain Modulation Effect on Neuropathic Pain Model-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Neurosurgery-
dc.contributor.googleauthorHyun Ho Jung-
dc.contributor.googleauthorJaewoo Shin-
dc.contributor.googleauthorJinhyung Kim-
dc.contributor.googleauthorSeung-Hee Ahn-
dc.contributor.googleauthorSung Eun Lee-
dc.contributor.googleauthorChin Su Koh-
dc.contributor.googleauthorJae Sung Cho-
dc.contributor.googleauthorChanho Kong-
dc.contributor.googleauthorHyung-Cheul Shin-
dc.contributor.googleauthorSung June Kim-
dc.contributor.googleauthorJin Woo Chang-
dc.identifier.doi10.1155/2016/3898924-
dc.contributor.localIdA03775-
dc.contributor.localIdA05042-
dc.contributor.localIdA03484-
dc.relation.journalcodeJ02319-
dc.identifier.eissn1687-5443-
dc.identifier.pmid27833762-
dc.contributor.alternativeNameChang, Jin Woo-
dc.contributor.alternativeNameJung, Hyun Ho-
dc.contributor.alternativeNameCho, Jae Sung-
dc.contributor.affiliatedAuthorJung, Hyun Ho-
dc.contributor.affiliatedAuthorCho, Jae Sung-
dc.contributor.affiliatedAuthorChang, Jin Woo-
dc.citation.volume2016-
dc.citation.startPage3898924-
dc.identifier.bibliographicCitationNEURAL PLASTICITY, Vol.2016 : 3898924, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid48611-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Yonsei Biomedical Research Center (연세의생명연구원) > 1. Journal Papers

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