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C-reactive Protein Concentration Is Associated With a Higher Risk of Mortality in a Rural Korean Population

 Jung Hyun Lee  ;  Hyungseon Yeom  ;  Hyeon Chang Kim  ;  Il Suh  ;  Mi Kyung Kim  ;  Min-Ho Shin  ;  Dong Hoon Shin  ;  Sang-Baek Koh  ;  Song Vogue Ahn  ;  Tae-Yong Lee  ;  So Yeon Ryu  ;  Jae-Sok Song  ;  Hong-Soon Choe  ;  Young-Hoon Lee  ;  Bo Youl Choi 
 Journal of Preventive Medicine and Public Health, Vol.49(5) : 275-287, 2016 
Journal Title
Journal of Preventive Medicine and Public Health
Issue Date
Aged ; Asian Continental Ancestry Group ; Biomarkers/blood ; C-Reactive Protein/analysis* ; Cardiovascular Diseases/blood ; Cardiovascular Diseases/mortality* ; Cause of Death ; Female ; Humans ; Male ; Middle Aged ; Proportional Hazards Models ; Republic of Korea ; Risk Factors ; Rural Population ; Sex Factors ; Survival Rate
C-reactive protein ; Cardiovascular diseases ; Mortality ; Republic of Korea ; Rural population
OBJECTIVES: C-reactive protein (CRP), an inflammatory biomarker, has been widely used as a preclinical marker predictive of morbidity and mortality. Although many studies have reported a positive association between CRP and mortality, uncertainty still remains about this association in various populations, especially in rural Korea.

METHODS: A total of 23 233 middle-aged participants (8862 men and 14 371 women) who were free from cardiovascular disease, cancer, and acute inflammation (defined by a CRP level ≥10 mg/L) were drawn from 11 rural communities in Korea between 2005 and 2011. Blood CRP concentration was analyzed as a categorical variable (low: 0.0-0.9 mg/L; intermediate: 1.0-3.0 mg/L; high: 3.1-9.9 mg/L) as well as a continuous variable. Each participant's vital status through December 2013 was confirmed by death statistics from the National Statistical Office. Cox proportional hazard models were used to assess the independent association between CRP and mortality after adjusting for other risk factors.

RESULTS: The total quantity of observed person-years was 57 975 for men and 95 146 for women, and the number of deaths was 649 among men and 367 among women. Compared to the low-CRP group, the adjusted hazard ratio for all-cause mortality of the intermediate group was 1.17 (95% confidence interval [CI], 0.98 to 1.40) for men and 1.27 (95% CI, 1.01 to 1.61) for women, and the corresponding values for the high-CRP group were 1.98 (95% CI, 1.61 to 2.42) for men and 1.41 (95% CI, 1.03 to 1.95) for women. Similar trends were found for CRP evaluated as a continuous variable and for cardiovascular mortality.

CONCLUSIONS: Higher CRP concentrations were associated with higher mortality in a rural Korean population, and this association was more prominent in men than in women.
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Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Preventive Medicine (예방의학교실) > 1. Journal Papers
4. Graduate School of Public Health (보건대학원) > Graduate School of Public Health (보건대학원) > 1. Journal Papers
Yonsei Authors
Kim, Hyeon Chang(김현창) ORCID logo https://orcid.org/0000-0001-7867-1240
Suh, Il(서일) ORCID logo https://orcid.org/0000-0002-9689-7849
Yeom, Hyung Seon(염형선)
Lee, Jung Hyun(이정현)
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