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Cell Migration According to Shape of Graphene Oxide Micropatterns

Authors
 Sung Eun Kim  ;  Min Sung Kim  ;  Yong Cheol Shin  ;  Seong Un Eom  ;  Jong Ho Lee  ;  Dong-Myeong Shin  ;  Suck Won Hong  ;  Bongju Kim  ;  Jong-Chul Park  ;  Bo Sung Shin  ;  Dohyung Lim  ;  Dong-Wook Han 
Citation
 Micromachines, Vol.7(10) : 186-186, 2016 
Journal Title
 Micromachines 
Issue Date
2016
Keywords
photolithography ; meniscus-dragging deposition ; graphene oxide ; micropatterns ; cell migration
Abstract
Photolithography is a unique process that can effectively manufacture micro/nano-sized patterns on various substrates. On the other hand, the meniscus-dragging deposition (MDD) process can produce a uniform surface of the substrate. Graphene oxide (GO) is the oxidized form of graphene that has high hydrophilicity and protein absorption. It is widely used in biomedical fields such as drug delivery, regenerative medicine, and tissue engineering. Herein, we fabricated uniform GO micropatterns via MDD and photolithography. The physicochemical properties of the GO micropatterns were characterized by atomic force microscopy (AFM), scanning electron microscopy (SEM), and Raman spectroscopy. Furthermore, cell migration on the GO micropatterns was investigated, and the difference in cell migration on triangle and square GO micropatterns was examined for their effects on cell migration. Our results demonstrated that the GO micropatterns with a desired shape can be finely fabricated via MDD and photolithography. Moreover, it was revealed that the shape of GO micropatterns plays a crucial role in cell migration distance, speed, and directionality. Therefore, our findings suggest that the GO micropatterns can serve as a promising biofunctional platform and cell-guiding substrate for applications to bioelectric devices, cell-on-a-chip, and tissue engineering scaffolds.
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T201604220.pdf Download
DOI
10.3390/mi7100186
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Medical Engineering (의학공학교실) > 1. Journal Papers
Yonsei Authors
박종철(Park, Jong Chul) ORCID logo https://orcid.org/0000-0003-0083-5991
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152372
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