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Synthesis and Characterization of Water-Soluble Conjugated Oligoelectrolytes for Near-Infrared Fluorescence Biological Imaging

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dc.contributor.author양재문-
dc.contributor.author구민희-
dc.date.accessioned2017-10-26T07:40:35Z-
dc.date.available2017-10-26T07:40:35Z-
dc.date.issued2016-
dc.identifier.issn1944-8244-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152365-
dc.description.abstractNear-infrared (NIR) fluorophores attract increasing attention as a molecular marker (or probe) for in vivo and in vitro biological fluorescence imaging. Three types of new NIR fluorescent conjugated oligoelectrolytes (COEs: Q-FlTBTTFl, Q-FlBBTFl, and Q-FlTBBTTFl) are synthesized with quaternized ammonium ionic groups in their side-chains for water solubility. The emission wavelength is modulated in the range 600-1300 nm, by adjusting the intramolecular charge transfer in the molecular backbone based on the electron-rich fluorene (and/or thiophene) and electron-deficient benzo[2,1,3]thiadiazole (or benzo[1,2-c:4,5-c']bis[1,2,5]thiadiazole) moieties. The COEs show a remarkably larger Stokes shift (147-276 nm) compared to commercial rhodamine and cyanine dyes in water, avoiding self-quenching and interference from the excitation backscattered light. The photoluminescence (PL) quantum efficiency is improved substantially by up to 27.8% in water by fabricating a vesicular complex, COE/v, with a block ionomer, poly[(ethylene oxide)-block-(sodium 2-acrylamido-2-methyl-1-propanesulfonate)]. In vitro cellular uptake images with the COEs are obtained with good biocompatibility by confocal single-photon and two-photon microscopy. The ex vivo and in vivo images of a mouse xenograft model treated with the Q-FlBBTFl/v exhibit a substantially stronger fluorescence signal at the tumor site than at the other organs, highlighting the potential of the COE/v as an NIR fluorescent imaging agent for the diagnosis of cancer-
dc.description.statementOfResponsibilityrestriction-
dc.publisherAmerican Chemical Society-
dc.relation.isPartOfACS APPLIED MATERIALS & INTERFACES-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSynthesis and Characterization of Water-Soluble Conjugated Oligoelectrolytes for Near-Infrared Fluorescence Biological Imaging-
dc.typeArticle-
dc.publisher.locationUnited States-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorShin-Jae Woo-
dc.contributor.googleauthorSungmin Park-
dc.contributor.googleauthorJi-Eun Jeong-
dc.contributor.googleauthorYoochan Hong-
dc.contributor.googleauthorMinhee Ku-
dc.contributor.googleauthorBo Yun Kim-
dc.contributor.googleauthorIl Ho Jang-
dc.contributor.googleauthorSoon Chul Heo-
dc.contributor.googleauthorTaejun Wang-
dc.contributor.googleauthorKi Hean Kim-
dc.contributor.googleauthorJaemoon Yang-
dc.contributor.googleauthorJae Ho Kim-
dc.contributor.googleauthorHan Young Woo-
dc.identifier.doi10.1021/acsami.6b04276-
dc.contributor.localIdA02315-
dc.contributor.localIdA00191-
dc.relation.journalcodeJ00004-
dc.identifier.eissn1944-8252-
dc.identifier.pmid27267787-
dc.identifier.urlhttp://pubs.acs.org/doi/abs/10.1021/acsami.6b04276-
dc.subject.keywordStokes shift-
dc.subject.keywordbioimaging-
dc.subject.keywordconjugated oligoelectrolytes-
dc.subject.keywordnear-infrared fluorophores-
dc.subject.keywordvesicle-
dc.contributor.alternativeNameYang, Jae Moon-
dc.contributor.affiliatedAuthorYang, Jae Moon-
dc.citation.volume8-
dc.citation.number25-
dc.citation.startPage15937-
dc.citation.endPage15947-
dc.identifier.bibliographicCitationACS APPLIED MATERIALS & INTERFACES, Vol.8(25) : 15937-15947, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid48098-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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