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Biomarker-specific conjugated nanopolyplexes for the active coloring of stem-like cancer cells

DC FieldValueLanguage
dc.contributor.author서진석-
dc.contributor.author양재문-
dc.date.accessioned2017-10-26T07:40:27Z-
dc.date.available2017-10-26T07:40:27Z-
dc.date.issued2016-
dc.identifier.issn0957-4484-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152361-
dc.description.abstractStem-like cancer cells possess intrinsic features and their CD44 regulate redox balance in cancer cells to survive under stress conditions. Thus, we have fabricated biomarker-specific conjugated polyplexes using CD44-targetable hyaluronic acid and redox-sensible polyaniline based on a nanoemulsion method. For the most sensitive recognition of the cellular redox at a single nanoparticle scale, a nano-scattering spectrum imaging analyzer system was introduced. The conjugated polyplexes showed a specific targeting ability toward CD44-expressing cancer cells as well as a dramatic change in its color, which depended on the redox potential in the light-scattered images. Therefore, these polyaniline-based conjugated polyplexes as well as analytical processes that include light-scattering imaging and measurements of scattering spectra, clearly establish a systematic method for the detection and monitoring of cancer microenvironments.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherIOP Pub.-
dc.relation.isPartOfNANOTECHNOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleBiomarker-specific conjugated nanopolyplexes for the active coloring of stem-like cancer cells-
dc.typeArticle-
dc.publisher.locationEngland-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorYoochan Hong-
dc.contributor.googleauthorEugene Lee-
dc.contributor.googleauthorJihye Choi-
dc.contributor.googleauthorSeungjoo Haam-
dc.contributor.googleauthorJin-Suck Suh-
dc.contributor.googleauthorJaemoon Yang-
dc.identifier.doi10.1088/0957-4484/27/22/225101-
dc.contributor.localIdA02315-
dc.contributor.localIdA01916-
dc.relation.journalcodeJ02287-
dc.identifier.eissn1361-6528-
dc.identifier.pmid27098318-
dc.identifier.urlhttp://iopscience.iop.org/article/10.1088/0957-4484/27/22/225101/meta-
dc.subject.keywordpolyaniline-
dc.subject.keywordhyaluronic acid-
dc.subject.keywordcancer-
dc.subject.keywordcolorimetric probes-
dc.subject.keywordredox environment-
dc.contributor.alternativeNameSuh, Jin Suck-
dc.contributor.alternativeNameYang, Jae Moon-
dc.contributor.affiliatedAuthorYang, Jae Moon-
dc.contributor.affiliatedAuthorSuh, Jin Suck-
dc.citation.volume27-
dc.citation.number22-
dc.citation.startPage225101-
dc.identifier.bibliographicCitationNANOTECHNOLOGY, Vol.27(22) : 225101, 2016-
dc.date.modified2017-10-24-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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