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Spinal cord fusion with PEG-GNRs (TexasPEG): Neurophysiological recovery in 24 hours in rats

Authors
 C-Yoon Kim  ;  William K. A. Sikkema  ;  In-Kyu Hwang  ;  Hanseul Oh  ;  Un Jeng Kim  ;  Bae Hwan Lee  ;  James M. Tour 
Citation
 Surgical Neurology International, Vol.7(Suppl. 24) : 632-636, 2016 
Journal Title
Surgical Neurology International
ISSN
 2229-5097 
Issue Date
2016
Keywords
Cephalosomatic anastomosis ; GEMINI ; electrophysiology ; graphene nanoribbons ; spinal cord fusion
Abstract
Background: The GEMINI spinal cord fusion protocol has been developed to achieve a successful cephalosomatic anastomosis. Here, for the first time, we report the effects of locally applied water-soluble, conductive PEG(polyethylene glycol)ylated graphene nanoribbons (PEG-GNRs) on neurophysiologic conduction after sharp cervical cord transection in rats. PEG-GNRs were produced by the polymerization of ethylene oxide from anion-edged graphene nanoribbons. These combine the fusogenic potential of PEG with the electrical conducting properties of the graphene nanoribbons.

Methods: Laminectomy and transection of cervical spinal cord (C5) was performed on Female Sprague-Dawley (SD) rats. After applying PEG-GNR on the severed part, electrophysiological recovery of the reconstructed cervical spinal cord was confirmed by somatosensory evoked potentials (SSEPs) at 24 h after surgery.

Results: While no SSEPs were detected in the control group, PEG-GNR treated group showed fast recovery of SSEPs at 24 h after the surgery.

Conclusion: In this preliminary dataset, for the first time, we report the effect of a novel form of PEG with the goal of rapid reconstruction of a sharply severed spinal cord.
Full Text
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025948/?report=printable
DOI
10.4103/2152-7806.190475
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers
Yonsei Authors
Kim, Un Jeng(김은정) ORCID logo https://orcid.org/0000-0003-0968-0252
Lee, Bae Hwan(이배환) ORCID logo https://orcid.org/0000-0003-4719-9021
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152358
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