Cited 19 times in
Spinal cord fusion with PEG-GNRs (TexasPEG): Neurophysiological recovery in 24 hours in rats
DC Field | Value | Language |
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dc.contributor.author | 이배환 | - |
dc.contributor.author | 김은정 | - |
dc.date.accessioned | 2017-10-26T07:40:22Z | - |
dc.date.available | 2017-10-26T07:40:22Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 2229-5097 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152358 | - |
dc.description.abstract | Background: The GEMINI spinal cord fusion protocol has been developed to achieve a successful cephalosomatic anastomosis. Here, for the first time, we report the effects of locally applied water-soluble, conductive PEG(polyethylene glycol)ylated graphene nanoribbons (PEG-GNRs) on neurophysiologic conduction after sharp cervical cord transection in rats. PEG-GNRs were produced by the polymerization of ethylene oxide from anion-edged graphene nanoribbons. These combine the fusogenic potential of PEG with the electrical conducting properties of the graphene nanoribbons. Methods: Laminectomy and transection of cervical spinal cord (C5) was performed on Female Sprague-Dawley (SD) rats. After applying PEG-GNR on the severed part, electrophysiological recovery of the reconstructed cervical spinal cord was confirmed by somatosensory evoked potentials (SSEPs) at 24 h after surgery. Results: While no SSEPs were detected in the control group, PEG-GNR treated group showed fast recovery of SSEPs at 24 h after the surgery. Conclusion: In this preliminary dataset, for the first time, we report the effect of a novel form of PEG with the goal of rapid reconstruction of a sharply severed spinal cord. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Medknow | - |
dc.relation.isPartOf | Surgical Neurology International | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Spinal cord fusion with PEG-GNRs (TexasPEG): Neurophysiological recovery in 24 hours in rats | - |
dc.type | Article | - |
dc.publisher.location | India | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Physiology | - |
dc.contributor.googleauthor | C-Yoon Kim | - |
dc.contributor.googleauthor | William K. A. Sikkema | - |
dc.contributor.googleauthor | In-Kyu Hwang | - |
dc.contributor.googleauthor | Hanseul Oh | - |
dc.contributor.googleauthor | Un Jeng Kim | - |
dc.contributor.googleauthor | Bae Hwan Lee | - |
dc.contributor.googleauthor | James M. Tour | - |
dc.identifier.doi | 10.4103/2152-7806.190475 | - |
dc.contributor.localId | A02791 | - |
dc.relation.journalcode | J03050 | - |
dc.relation.journalsince | 2010 | - |
dc.identifier.pmid | 27656326 | - |
dc.identifier.url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025948/?report=printable | - |
dc.subject.keyword | Cephalosomatic anastomosis | - |
dc.subject.keyword | GEMINI | - |
dc.subject.keyword | electrophysiology | - |
dc.subject.keyword | graphene nanoribbons | - |
dc.subject.keyword | spinal cord fusion | - |
dc.contributor.alternativeName | Lee, Bae Hwan | - |
dc.contributor.affiliatedAuthor | Lee, Bae Hwan | - |
dc.citation.volume | 7 | - |
dc.citation.number | Suppl. 24 | - |
dc.citation.startPage | 632 | - |
dc.citation.endPage | 636 | - |
dc.identifier.bibliographicCitation | Surgical Neurology International, Vol.7(Suppl. 24) : 632-636, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 48093 | - |
dc.type.rims | ART | - |
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