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Spinal cord fusion with PEG-GNRs (TexasPEG): Neurophysiological recovery in 24 hours in rats

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dc.contributor.author이배환-
dc.contributor.author김은정-
dc.date.accessioned2017-10-26T07:40:22Z-
dc.date.available2017-10-26T07:40:22Z-
dc.date.issued2016-
dc.identifier.issn2229-5097-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152358-
dc.description.abstractBackground: The GEMINI spinal cord fusion protocol has been developed to achieve a successful cephalosomatic anastomosis. Here, for the first time, we report the effects of locally applied water-soluble, conductive PEG(polyethylene glycol)ylated graphene nanoribbons (PEG-GNRs) on neurophysiologic conduction after sharp cervical cord transection in rats. PEG-GNRs were produced by the polymerization of ethylene oxide from anion-edged graphene nanoribbons. These combine the fusogenic potential of PEG with the electrical conducting properties of the graphene nanoribbons. Methods: Laminectomy and transection of cervical spinal cord (C5) was performed on Female Sprague-Dawley (SD) rats. After applying PEG-GNR on the severed part, electrophysiological recovery of the reconstructed cervical spinal cord was confirmed by somatosensory evoked potentials (SSEPs) at 24 h after surgery. Results: While no SSEPs were detected in the control group, PEG-GNR treated group showed fast recovery of SSEPs at 24 h after the surgery. Conclusion: In this preliminary dataset, for the first time, we report the effect of a novel form of PEG with the goal of rapid reconstruction of a sharply severed spinal cord.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherMedknow-
dc.relation.isPartOfSurgical Neurology International-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.titleSpinal cord fusion with PEG-GNRs (TexasPEG): Neurophysiological recovery in 24 hours in rats-
dc.typeArticle-
dc.publisher.locationIndia-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Physiology-
dc.contributor.googleauthorC-Yoon Kim-
dc.contributor.googleauthorWilliam K. A. Sikkema-
dc.contributor.googleauthorIn-Kyu Hwang-
dc.contributor.googleauthorHanseul Oh-
dc.contributor.googleauthorUn Jeng Kim-
dc.contributor.googleauthorBae Hwan Lee-
dc.contributor.googleauthorJames M. Tour-
dc.identifier.doi10.4103/2152-7806.190475-
dc.contributor.localIdA02791-
dc.relation.journalcodeJ03050-
dc.relation.journalsince2010-
dc.identifier.pmid27656326-
dc.identifier.urlhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC5025948/?report=printable-
dc.subject.keywordCephalosomatic anastomosis-
dc.subject.keywordGEMINI-
dc.subject.keywordelectrophysiology-
dc.subject.keywordgraphene nanoribbons-
dc.subject.keywordspinal cord fusion-
dc.contributor.alternativeNameLee, Bae Hwan-
dc.contributor.affiliatedAuthorLee, Bae Hwan-
dc.citation.volume7-
dc.citation.numberSuppl. 24-
dc.citation.startPage632-
dc.citation.endPage636-
dc.identifier.bibliographicCitationSurgical Neurology International, Vol.7(Suppl. 24) : 632-636, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid48093-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Physiology (생리학교실) > 1. Journal Papers

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