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Common variants of HTR3 genes are associated with obsessive-compulsive disorder and its phenotypic expression

 Hae Won Kim  ;  Jee In Kang  ;  Sang-Hyuk Lee  ;  Suk Kyoon An  ;  Sung Yun Sohn  ;  Eun Hee Hwang  ;  Su Young Lee  ;  Se Joo Kim 
 Scientific Reports, Vol.6 : 32564, 2016 
Journal Title
 Scientific Reports 
Issue Date
Adult ; Female ; Genetic Association Studies* ; Genetic Predisposition to Disease* ; Genotype ; Haplotypes/genetics ; Humans ; Male ; Middle Aged ; Obsessive-Compulsive Disorder/genetics* ; Obsessive-Compulsive Disorder/pathology ; Phenotype ; Polymorphism, Single Nucleotide/genetics ; Receptors, Serotonin, 5-HT3/genetics*
Evidence from literature supports the existence of associations between serotonin-related genetic variants and obsessive-compulsive disorder (OCD), but few studies have explored the involvement of serotonin receptor type 3 genes (HTR3) in OCD. To identify whether HTR3 variability affects an individual's susceptibility to OCD, we examined 10 HTR3 variants in 596 individuals with OCD and 599 controls. A significant difference existed in the genotypic distribution of the HTR3B variant rs1176744 between individuals with OCD and controls (odds ratio [OR]?=?0.74, 95% confidence interval [CI]?=?0.60-0.91, P?=?0.0043). A protective haplotype in HTR3B was also associated with OCD (OR?=?0.77, CI?=?0.63-0.95, permutated P?=?0.0179). Analyses of OCD sub-phenotypes demonstrated significant associations between rs3758987 and early onset OCD in male subjects (OR?=?0.49, CI?=?0.31-0.79, P?=?0.0031) and among rs6766410, rs6443930, and the cleaning dimension in female subjects (OR?=?0.36, CI?=?0.18-0.69, P?=?0.0016 and OR?=?0.47, CI?=?0.29-0.79, P?=?0.0030, respectively). Additionally, rs6766410 was related to contamination-based disgust in OCD (P?=?0.0044). These results support that common HTR3 variants are involved in OCD and some of its clinical phenotypes.
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1. College of Medicine (의과대학) > Dept. of Psychiatry (정신과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Medical Education (의학교육학과) > 1. Journal Papers
Yonsei Authors
Kang, Jee In(강지인) ORCID logo https://orcid.org/0000-0002-2818-7183
Kim, Se Joo(김세주) ORCID logo https://orcid.org/0000-0002-5438-8210
Kim, Hae Won(김혜원) ORCID logo https://orcid.org/0000-0002-9321-8361
Sohn, Sung Yun(손성연)
An, Suk Kyoon(안석균) ORCID logo https://orcid.org/0000-0003-4576-6184
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