Cited 29 times in
Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A)
DC Field | Value | Language |
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dc.contributor.author | 강석구 | - |
dc.contributor.author | 김선호 | - |
dc.contributor.author | 김세훈 | - |
dc.contributor.author | 김의현 | - |
dc.contributor.author | 전정용 | - |
dc.contributor.author | 육종인 | - |
dc.contributor.author | 정재호 | - |
dc.contributor.author | 윤미진 | - |
dc.contributor.author | 허용민 | - |
dc.contributor.author | 장종희 | - |
dc.contributor.author | 이지현 | - |
dc.date.accessioned | 2017-10-26T07:38:11Z | - |
dc.date.available | 2017-10-26T07:38:11Z | - |
dc.date.issued | 2016 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152309 | - |
dc.description.abstract | Studies have investigated biguanide-derived agents for the treatment of cancers and have reported their effects against tumorspheres (TSs). The purpose of this study was determining the effects of HL156A, a newly designed biguanide with improved pharmacokinetics, on glioblastoma TSs (GMB TSs) and assess the feasibility of this drug as a new line of therapy against glioblastoma, alone or combined with a conventional therapeutic agent, temozolomide(TMZ). The effects of HL156A, alone and combined with TMZ, on the stemness and invasive properties of GBM TSs and survival of orthotopic xenograft animals were assessed. HL156A, combined with TMZ, inhibited the stemness of GBM TSs, proven by neurosphere formation assay and marker expression. Three-dimensional collagen matrix invasion assays provided evidence that combined treatment inhibited invasive properties, compared with control and TMZ-alone treatment groups. TMZ alone and combined treatment repressed the expression of epithelial-mesenchymal transition-related genes. A gene ontology comparison of TMZ and combination-treatment groups revealed altered expression of genes encoding proteins involved in cellular adhesion and migration. Combined treatment with HL156A and TMZ showed survival benefits in an orthotopic xenograft mouse model. The inhibitory effect of combination treatment on the stemness and invasive properties of GBM TSs suggest the potential usage of this regimen as a novel strategy for the treatment of GBM. | - |
dc.description.statementOfResponsibility | open | - |
dc.format | application/pdf | - |
dc.language | English | - |
dc.publisher | Impact Journals | - |
dc.relation.isPartOf | ONCOTARGET | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Animals | - |
dc.subject.MESH | Antineoplastic Agents, Alkylating/pharmacology* | - |
dc.subject.MESH | Apoptosis/drug effects | - |
dc.subject.MESH | Brain Neoplasms/drug therapy | - |
dc.subject.MESH | Brain Neoplasms/pathology* | - |
dc.subject.MESH | Cell Proliferation/drug effects | - |
dc.subject.MESH | Dacarbazine/analogs & derivatives* | - |
dc.subject.MESH | Dacarbazine/pharmacology | - |
dc.subject.MESH | Drug Therapy, Combination | - |
dc.subject.MESH | Epithelial-Mesenchymal Transition/drug effects | - |
dc.subject.MESH | Gene Expression Regulation, Neoplastic/drug effects* | - |
dc.subject.MESH | Glioblastoma/drug therapy | - |
dc.subject.MESH | Glioblastoma/pathology* | - |
dc.subject.MESH | Guanidines/pharmacology* | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Mice | - |
dc.subject.MESH | Mice, Inbred ICR | - |
dc.subject.MESH | Mice, Nude | - |
dc.subject.MESH | Neoplasm Invasiveness | - |
dc.subject.MESH | Neoplastic Stem Cells/drug effects | - |
dc.subject.MESH | Neoplastic Stem Cells/pathology* | - |
dc.subject.MESH | Pyrrolidines/pharmacology* | - |
dc.subject.MESH | Tumor Cells, Cultured | - |
dc.subject.MESH | Xenograft Model Antitumor Assays | - |
dc.title | Inhibiting stemness and invasive properties of glioblastoma tumorsphere by combined treatment with temozolomide and a newly designed biguanide (HL156A) | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Neurosurgery | - |
dc.contributor.googleauthor | Junjeong Choi | - |
dc.contributor.googleauthor | Ji-Hyun Lee | - |
dc.contributor.googleauthor | Ilkyoo Koh | - |
dc.contributor.googleauthor | Jin-Kyoung Shim | - |
dc.contributor.googleauthor | Junseong Park | - |
dc.contributor.googleauthor | Jeong Yong Jeon | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.contributor.googleauthor | Se Hoon Kim | - |
dc.contributor.googleauthor | Jong In Yook | - |
dc.contributor.googleauthor | Eui Hyun Kim | - |
dc.contributor.googleauthor | Jong Hee Chang | - |
dc.contributor.googleauthor | Sun Ho Kim | - |
dc.contributor.googleauthor | Yong Min Huh | - |
dc.contributor.googleauthor | Su Jae Lee | - |
dc.contributor.googleauthor | Michael Pollak | - |
dc.contributor.googleauthor | Pilnam Kim | - |
dc.contributor.googleauthor | Seok-Gu Kang | - |
dc.contributor.googleauthor | Jae-Ho Cheong | - |
dc.identifier.doi | 10.18632/oncotarget.11595 | - |
dc.contributor.localId | A00560 | - |
dc.contributor.localId | A00610 | - |
dc.contributor.localId | A00837 | - |
dc.contributor.localId | A04512 | - |
dc.contributor.localId | A02536 | - |
dc.contributor.localId | A03717 | - |
dc.contributor.localId | A02550 | - |
dc.contributor.localId | A04359 | - |
dc.contributor.localId | A03470 | - |
dc.contributor.localId | A03218 | - |
dc.contributor.localId | A00036 | - |
dc.relation.journalcode | J02421 | - |
dc.identifier.eissn | 1949-2553 | - |
dc.identifier.pmid | 27582539 | - |
dc.subject.keyword | HL156A | - |
dc.subject.keyword | biguanide | - |
dc.subject.keyword | glioblastoma | - |
dc.subject.keyword | invasion | - |
dc.subject.keyword | tumorsphere | - |
dc.contributor.alternativeName | Kang, Seok Gu | - |
dc.contributor.alternativeName | Kim, Sun Ho | - |
dc.contributor.alternativeName | Kim, Se Hoon | - |
dc.contributor.alternativeName | Kim, Eui Hyun | - |
dc.contributor.alternativeName | Jeon, Jeong Yong | - |
dc.contributor.alternativeName | Yook, Jong In | - |
dc.contributor.alternativeName | Cheong, Jae Ho | - |
dc.contributor.alternativeName | Yun, Mi Jin | - |
dc.contributor.alternativeName | Huh, Yong Min | - |
dc.contributor.alternativeName | Chang, Jong Hee | - |
dc.contributor.affiliatedAuthor | Kim, Sun Ho | - |
dc.contributor.affiliatedAuthor | Kim, Se Hoon | - |
dc.contributor.affiliatedAuthor | Kim, Eui Hyun | - |
dc.contributor.affiliatedAuthor | Jeon, Jeong Yong | - |
dc.contributor.affiliatedAuthor | Yook, Jong In | - |
dc.contributor.affiliatedAuthor | Cheong, Jae Ho | - |
dc.contributor.affiliatedAuthor | Yun, Mi Jin | - |
dc.contributor.affiliatedAuthor | Huh, Yong Min | - |
dc.contributor.affiliatedAuthor | Chang, Jong Hee | - |
dc.contributor.affiliatedAuthor | Lee, Ji Hyun | - |
dc.contributor.affiliatedAuthor | Kang, Seok Gu | - |
dc.citation.volume | 7 | - |
dc.citation.number | 40 | - |
dc.citation.startPage | 65643 | - |
dc.citation.endPage | 65659 | - |
dc.identifier.bibliographicCitation | ONCOTARGET , Vol.7(40) : 65643-65659, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 48044 | - |
dc.type.rims | ART | - |
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