0 113

Cited 3 times in

Diabetic retinal pigment epitheliopathy: fundus autofluorescence and spectral-domain optical coherence tomography findings

Authors
 Eui Chun Kang  ;  Yuri Seo  ;  Suk Ho Byeon 
Citation
 GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY, Vol.254(10) : 1931-1940, 2016 
Journal Title
 GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY 
ISSN
 0721-832X 
Issue Date
2016
MeSH
Adult ; Aged ; Choroid/diagnostic imaging ; Choroid/pathology ; Diabetic Retinopathy/diagnostic imaging* ; Diabetic Retinopathy/physiopathology ; Female ; Fundus Oculi ; Humans ; Male ; Middle Aged ; Optical Imaging* ; Retina/diagnostic imaging ; Retina/pathology ; Retinal Pigment Epithelium/diagnostic imaging* ; Retinal Pigment Epithelium/pathology ; Retrospective Studies ; Tomography, Optical Coherence* ; Visual Acuity/physiology
Keywords
Diabetic retinal pigment epitheliopathy ; Fundus autofluorescence ; Proliferative diabetic retinopathy ; Spectral-domain optical coherence tomography
Abstract
PURPOSE: To describe the characteristics of an unfamiliar disease entity, diabetic retinal pigment epitheliopathy (DRPE), using fundus autofluorescence (FAF) and spectral-domain optical coherence tomography (SD-OCT). METHODS: This retrospective study included 17 eyes from 10 proliferative diabetic retinopathy (PDR) patients with granular hypo-autofluorescence and/or variable hyper-autofluorescence on FAF (DRPE group) and 17 eyes from 10 age- and sex-matched PDR patients without abnormal autofluorescence (PDR group). Eyes with diabetic macular edema were excluded. Visual acuity (VA), retinal thickness (RT), and choroidal thickness (CT) were compared between the groups. RESULTS: Eyes in the DRPE group had worse logMAR VA than eyes in the PDR group (0.369?±?0.266 vs. 0.185?±?0.119; P?=?0.026). The thickness of the retinal pigment epithelium plus the inner segment/outer segment of the photoreceptors was reduced to a greater degree in the DRPE group than the PDR group (P?<?0.001). Moreover, the thickness of the outer nuclear layer plus the outer plexiform layer was thinner in the DRPE group than in the PDR (P?=?0.013). However, the thickness of the inner retina showed no differences between the two groups. CT was significantly thicker in the DRPE group than in the PDR group (329.00?±?33.76 vs. 225.62?±?37.47 μm; P?<?0.001). CONCLUSIONS: Eyes with DRPE showed reduced VA, a thinner outer retina, and thicker choroid in comparison with eyes with PDR. Alterations of autofluorescence on FAF and changes in the outer retinal thickness and CT on SD-OCT can be helpful for differentiating DRPE in patients with PDR.
Full Text
https://link.springer.com/article/10.1007%2Fs00417-016-3336-8
DOI
10.1007/s00417-016-3336-8
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Ophthalmology (안과학교실) > 1. Journal Papers
Yonsei Authors
Kang, Eui Chun(강의천)
Byeon, Suk Ho(변석호) ORCID logo https://orcid.org/0000-0001-8101-0830
Seo, Yuri(서유리)
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152275
사서에게 알리기
  feedback

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

Browse