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중추신경계 생식세포종양의 최근 치료 경향

Other Titles
 Current Trends in Management for Central Nervous System Germ Cell Tumor 
Authors
 한정우  ;  고경남  ;  김지윤  ;  백희조  ;  이지원  ;  심규원  ;  조재호  ;  김동석 
Citation
 Clinical Pediatric Hematology-Oncology, Vol.23(1) : 17-27, 2016 
Journal Title
 Clinical Pediatric Hematology-Oncology 
ISSN
 2233-5250 
Issue Date
2016
Keywords
Neoplasms ; Germ cell and embryonal ; Brain neoplasms ; Germinoma ; Neoplasms
Abstract
Central nervous system germ cell tumor is a rare but important tumor in childhood brain tumors. It requires a multidisciplinary approach to increase survival and promote quality of life, and all three treatment modalities including surgery, radiotherapy and chemo-therapy has its own distinct role for germ cell tumor. For germinoma, radiotherapy alone can cure the disease but, the effort to limit the long term toxicity and the proper combi-nation of chemotherapy and radiotherapy are under investigation. Craniospinal irradi-ation is reserved only for the disseminated germinoma or nongerminomatous germ cell tumor (NGGCT). For germinoma, craniospinal irradiation of 20 to 24 Gy is sufficient to control microscopic disease in the spinal axis. Chemotherapy and radiotherapy com-posed of 30 to 40 Gy of local field radiotherapy and 20 to 24 Gy of whole ventricular irradiation are required for localized germinoma, but the proper combination of two modalities has yet to be defined. For NGGCT, both the chemotherapy and radiotherapy should be performed, and survival rate is substantially increasing with modern treatment protocols. The omission of craniospinal irradiation is being tried for the localized NGGCT in international cooperative group trials. Surgery has its role for the resection of residual disease after the treatment, and the extent of resection in NGGCT has the prognostic implication. Bifocal germ cell tumors and basal ganglia germ cell tumor have distinctive clinical course and mandate special attention. To advance clinical and biological per-spectives in central nervous germ cell tumor, the cooperation and communication of the multidisciplinary specialists are essential.
Files in This Item:
T201604038.pdf Download
DOI
10.15264/cpho.2016.23.1.17
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Pediatrics (소아청소년과학교실) > 1. Journal Papers
Yonsei Authors
Kim, Dong Seok(김동석)
Shim, Kyu Won(심규원) ORCID logo https://orcid.org/0000-0002-9441-7354
Cho, Jae Ho(조재호) ORCID logo https://orcid.org/0000-0001-9966-5157
Han, Jung Woo(한정우) ORCID logo https://orcid.org/0000-0001-8936-1205
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152242
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