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Eribulin Mesylate Combined with Local Treatment for Brain Metastasis from Breast Cancer: Two Case Reports

Authors
 Kyung-Do Byun  ;  Sung Gwe Ahn  ;  Hyung Joo Baik  ;  Anbok Lee  ;  Ki Beom Bae  ;  Min Sung An  ;  Kwang Hee Kim  ;  Jae Ho Shin  ;  Ha Kyoung Park  ;  Heunglae Cho  ;  Joon Jeong  ;  Tae Hyun Kim 
Citation
 JOURNAL OF BREAST CANCER, Vol.19(2) : 214-217, 2016 
Journal Title
 JOURNAL OF BREAST CANCER 
ISSN
 1738-6756 
Issue Date
2016
Keywords
Brain ; Breast neoplasms ; Eribulin ; Neoplasm metastasis
Abstract
The prognosis associated with brain metastasis arising from breast cancer is very poor. Eribulin is a microtubule dynamic inhibitor synthesized from halichondrin B, a natural marine product. In a phase III study (EMBRACE), eribulin improved overall survival in patients with heavily pretreated metastatic breast cancers. However, these studies included few patients with brain metastases. Metastatic brain tumors (MBT) were detected during first-line palliative chemotherapy in a 43-year-old woman with breast cancer metastasis to the lung and mediastinal nodes; the genetic subtype was luminal B-like human epidermal growth factor receptor 2 (HER2)-negative. Whole brain radiotherapy (WBRT) followed by eribulin treatment continuously decreased the size, and induced regression, of the MBT with systemic disease stability for 12 months. Another 48-year-old woman with metastatic breast cancer (HER2+ subtype) presented with MBT. Following surgical resection of the tumor, eribulin with concurrent WBRT showed regression of the MBT without systemic progression for 18 months.
Files in This Item:
T201603819.pdf Download
DOI
10.4048/jbc.2016.19.2.214
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Surgery (외과학교실) > 1. Journal Papers
Yonsei Authors
Ahn, Sung Gwe(안성귀) ORCID logo https://orcid.org/0000-0002-8778-9686
Jeong, Joon(정준) ORCID logo https://orcid.org/0000-0003-0397-0005
URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152227
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