Cited 4 times in
Radiological-pathological correlation study of hepatocellular carcinoma undergoing local chemoradiotherapy and surgery
DC Field | Value | Language |
---|---|---|
dc.contributor.author | 금기창 | - |
dc.contributor.author | 김경식 | - |
dc.contributor.author | 김준원 | - |
dc.contributor.author | 박미숙 | - |
dc.contributor.author | 박영년 | - |
dc.contributor.author | 성진실 | - |
dc.contributor.author | 이익재 | - |
dc.contributor.author | 한광협 | - |
dc.date.accessioned | 2017-10-26T07:34:55Z | - |
dc.date.available | 2017-10-26T07:34:55Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 0815-9319 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152220 | - |
dc.description.abstract | BACKGROUND AND AIMS: Optimal response criteria and assessment timing were investigated through radiologic-pathologic correlation in hepatocellular carcinoma (HCC) treated with localized chemoradiotherapy (CRT). METHODS: We reviewed 19 consecutive HCC patients who underwent surgical resection after radiotherapy and concurrent hepatic arterial infusion chemotherapy. Patients who received transarterial chemoembolization before RT or surgery were excluded from evaluation. Tumor diameters and total and enhancing tumor volumes were measured from CT images obtained 1, 3, 6, and 9?months after CRT. Percent changes calculated using size (RECIST and WHO) and enhancement criteria (mRECIST and EASL) were correlated with percent changes in total and enhancing tumor volumes, and with percent viable tumor in surgical specimens. RESULTS: Median time between CRT and resection was 4.1?months (range, 1.5-15.4?months). CR and PR rates were 0 and 68% by RECIST, 0 and 63% by WHO, 53% and 37% by mRECIST, and 53% and 42% by EASL. Pathologic CR (pCR) rate was 52.6%. Radiologic criteria showed strong correlation with tumor volumes at 1 and 3?months after CRT; at 6?months, however, size and enhancement criteria showed strong correlation only with total and enhancing tumor volumes, respectively. Enhancement criteria were better predictors of pathologic response at all times including preoperative evaluation (RECIST: R(2) ?=?0.303, P?=?0.015 and WHO: R(2) ?=?0.366, P?=?0.006 vs. mRECIST: R(2) ?=?0.760, P?<?0.0001 and EASL: R(2) ?=?0.768, P?<?0.0001). Time interval >6?months before resection showed significant correlation with pCR (P?=?0.013). CONCLUSIONS: We recommend using enhancement criteria in assessing tumor viability, especially if the tumor was to be resected <6?months after CRT. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | Blackwell Scientific Publications | - |
dc.relation.isPartOf | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.title | Radiological-pathological correlation study of hepatocellular carcinoma undergoing local chemoradiotherapy and surgery | - |
dc.type | Article | - |
dc.publisher.location | Australia | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiation Oncology | - |
dc.contributor.googleauthor | Jun Won Kim | - |
dc.contributor.googleauthor | Jinsil Seong | - |
dc.contributor.googleauthor | Mi Sook Park | - |
dc.contributor.googleauthor | Kyung Sik Kim | - |
dc.contributor.googleauthor | Young Nyun Park | - |
dc.contributor.googleauthor | Kwang Hyub Han | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.contributor.googleauthor | Ik Jae Lee | - |
dc.identifier.doi | 10.1111/jgh.13334 | - |
dc.contributor.localId | A00299 | - |
dc.contributor.localId | A00958 | - |
dc.contributor.localId | A01463 | - |
dc.contributor.localId | A01563 | - |
dc.contributor.localId | A01956 | - |
dc.contributor.localId | A03055 | - |
dc.contributor.localId | A04268 | - |
dc.contributor.localId | A00272 | - |
dc.relation.journalcode | J01417 | - |
dc.identifier.eissn | 1440-1746 | - |
dc.identifier.pmid | 26969151 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1111/jgh.13334/abstract | - |
dc.subject.keyword | hepatocellular carcinoma | - |
dc.subject.keyword | localized chemoradiotherapy | - |
dc.subject.keyword | radiologic-pathologic correlation. | - |
dc.contributor.alternativeName | Keum, Ki Chang | - |
dc.contributor.alternativeName | Kim, Kyung Sik | - |
dc.contributor.alternativeName | Kim, Jun Won | - |
dc.contributor.alternativeName | Park, Mi Sook | - |
dc.contributor.alternativeName | Park, Young Nyun | - |
dc.contributor.alternativeName | Seong, Jin Sil | - |
dc.contributor.alternativeName | Lee, Ik Jae | - |
dc.contributor.alternativeName | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Kim, Kyung Sik | - |
dc.contributor.affiliatedAuthor | Kim, Jun Won | - |
dc.contributor.affiliatedAuthor | Park, Mi-Suk | - |
dc.contributor.affiliatedAuthor | Park, Young Nyun | - |
dc.contributor.affiliatedAuthor | Seong, Jin Sil | - |
dc.contributor.affiliatedAuthor | Lee, Ik Jae | - |
dc.contributor.affiliatedAuthor | Han, Kwang Hyup | - |
dc.contributor.affiliatedAuthor | Keum, Ki Chang | - |
dc.citation.volume | 31 | - |
dc.citation.number | 9 | - |
dc.citation.startPage | 1619 | - |
dc.citation.endPage | 1627 | - |
dc.identifier.bibliographicCitation | JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY, Vol.31(9) : 1619-1627, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 46997 | - |
dc.type.rims | ART | - |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.