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Genetic Abnormalities in Oral Leukoplakia and Oral Cancer Progression

 Tae Jun Kil  ;  Hyun Sil Kim  ;  Hyung Jun Kim  ;  Woong Nam  ;  In-Ho Cha 
 Asian Pacific Journal of Cancer Prevention, Vol.17(6) : 3001-3006, 2016 
Journal Title
 Asian Pacific Journal of Cancer Prevention 
Issue Date
Adult ; Aged ; Biomarkers, Tumor/genetics* ; Carcinoma, Squamous Cell/genetics* ; Carcinoma, Squamous Cell/pathology ; Case-Control Studies ; DNA Copy Number Variations/genetics* ; Female ; Follow-Up Studies ; Humans ; Leukoplakia, Oral/genetics* ; Leukoplakia, Oral/pathology ; Longitudinal Studies ; Male ; Middle Aged ; Mouth Mucosa/metabolism* ; Mouth Mucosa/pathology ; Mouth Neoplasms/genetics* ; Mouth Neoplasms/pathology ; Neoplasm Staging ; Precancerous Conditions/genetics* ; Precancerous Conditions/pathology ; Prognosis
Copy number variation ; Oral leukoplakia ; Biomarker ; cancer progression
BACKGROUND: The cancer progression of oral leukoplakia is an important watchpoint in the follow-up observation of the patients. However, potential malignancies of oral leukoplakia cannot be estimated by histopathologic assessment alone. We evaluated genetic abnormalities at the level of copy number variation (CNV) to investigate the risk for developing cancer in oral leukoplakias. MATERIALS AND METHODS: The current study used 27 oral leukoplakias with histological evidence of dysplasia. The first group (progressing dysplasia) consisted of 7 oral lesions from patients with later progression to cancer at the same site. The other group (non- progressing dysplasia) consisted of 20 lesions from patients with no occurrence of oral cancer and longitudinal follow up (>7 years). We extracted DNA from Formalin-Fixed Paraffin-Embedded (FFPE) samples and examined chromosomal loci and frequencies of CNVs using Taqman copy number assays. RESULTS: CNV frequently occurred at 3p, 9p, and 13q loci in progressing dysplasia. Our results also indicate that CNV at multiple loci-in contrast to single locus occurrences-is characteristic of progressing dysplasia. CONCLUSIONS: This study suggests that genetic abnormalities of the true precancer demonstrate the progression risk which cannot be delineated by current histopathologic diagnosis.
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2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers
Yonsei Authors
김현실(Kim, Hyun Sil) ORCID logo https://orcid.org/0000-0003-3614-1764
김형준(Kim, Hyung Jun) ORCID logo https://orcid.org/0000-0001-8247-4004
남웅(Nam, Woong) ORCID logo https://orcid.org/0000-0003-0146-3624
차인호(Cha, In Ho) ORCID logo https://orcid.org/0000-0001-8259-2190
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