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Genetic Abnormalities in Oral Leukoplakia and Oral Cancer Progression

DC Field Value Language
dc.contributor.author김현실-
dc.contributor.author남웅-
dc.contributor.author차인호-
dc.contributor.author김형준-
dc.date.accessioned2017-10-26T07:34:47Z-
dc.date.available2017-10-26T07:34:47Z-
dc.date.issued2016-
dc.identifier.issn1513-7368-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152216-
dc.description.abstractBACKGROUND: The cancer progression of oral leukoplakia is an important watchpoint in the follow-up observation of the patients. However, potential malignancies of oral leukoplakia cannot be estimated by histopathologic assessment alone. We evaluated genetic abnormalities at the level of copy number variation (CNV) to investigate the risk for developing cancer in oral leukoplakias. MATERIALS AND METHODS: The current study used 27 oral leukoplakias with histological evidence of dysplasia. The first group (progressing dysplasia) consisted of 7 oral lesions from patients with later progression to cancer at the same site. The other group (non- progressing dysplasia) consisted of 20 lesions from patients with no occurrence of oral cancer and longitudinal follow up (>7 years). We extracted DNA from Formalin-Fixed Paraffin-Embedded (FFPE) samples and examined chromosomal loci and frequencies of CNVs using Taqman copy number assays. RESULTS: CNV frequently occurred at 3p, 9p, and 13q loci in progressing dysplasia. Our results also indicate that CNV at multiple loci-in contrast to single locus occurrences-is characteristic of progressing dysplasia. CONCLUSIONS: This study suggests that genetic abnormalities of the true precancer demonstrate the progression risk which cannot be delineated by current histopathologic diagnosis.-
dc.description.statementOfResponsibilityopen-
dc.publisherAsian Pacific Organization for Cancer Prevention-
dc.relation.isPartOfASIAN PACIFIC JOURNAL OF CANCER PREVENTION-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHBiomarkers, Tumor/genetics*-
dc.subject.MESHCarcinoma, Squamous Cell/genetics*-
dc.subject.MESHCarcinoma, Squamous Cell/pathology-
dc.subject.MESHCase-Control Studies-
dc.subject.MESHDNA Copy Number Variations/genetics*-
dc.subject.MESHFemale-
dc.subject.MESHFollow-Up Studies-
dc.subject.MESHHumans-
dc.subject.MESHLeukoplakia, Oral/genetics*-
dc.subject.MESHLeukoplakia, Oral/pathology-
dc.subject.MESHLongitudinal Studies-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHMouth Mucosa/metabolism*-
dc.subject.MESHMouth Mucosa/pathology-
dc.subject.MESHMouth Neoplasms/genetics*-
dc.subject.MESHMouth Neoplasms/pathology-
dc.subject.MESHNeoplasm Staging-
dc.subject.MESHPrecancerous Conditions/genetics*-
dc.subject.MESHPrecancerous Conditions/pathology-
dc.subject.MESHPrognosis-
dc.titleGenetic Abnormalities in Oral Leukoplakia and Oral Cancer Progression-
dc.typeArticle-
dc.publisher.locationThailand-
dc.contributor.collegeCollege of Dentistry-
dc.contributor.departmentDept. of Oral Pathology-
dc.contributor.googleauthorTae Jun Kil-
dc.contributor.googleauthorHyun Sil Kim-
dc.contributor.googleauthorHyung Jun Kim-
dc.contributor.googleauthorWoong Nam-
dc.contributor.googleauthorIn-Ho Cha-
dc.contributor.localIdA01260-
dc.contributor.localIdA04002-
dc.contributor.localIdA01156-
dc.contributor.localIdA01121-
dc.relation.journalcodeJ00255-
dc.identifier.eissn2476-762X-
dc.identifier.pmid27356725-
dc.subject.keywordCopy number variation-
dc.subject.keywordOral leukoplakia-
dc.subject.keywordBiomarker-
dc.subject.keywordcancer progression-
dc.contributor.alternativeNameKim, Hyun Sil-
dc.contributor.alternativeNameNam, Woong-
dc.contributor.alternativeNameCha, In Ho-
dc.contributor.alternativeNameKim, Hyung Jun-
dc.contributor.affiliatedAuthorNam, Woong-
dc.contributor.affiliatedAuthorCha, In Ho-
dc.contributor.affiliatedAuthorKim, Hyung Jun-
dc.contributor.affiliatedAuthorKim, Hyun Sil-
dc.citation.volume17-
dc.citation.number6-
dc.citation.startPage3001-
dc.citation.endPage3006-
dc.identifier.bibliographicCitationASIAN PACIFIC JOURNAL OF CANCER PREVENTION, Vol.17(6) : 3001-3006, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid46993-
dc.type.rimsART-
Appears in Collections:
2. College of Dentistry (치과대학) > Dept. of Oral Pathology (구강병리학교실) > 1. Journal Papers
2. College of Dentistry (치과대학) > Dept. of Oral and Maxillofacial Surgery (구강악안면외과학교실) > 1. Journal Papers

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