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Steroidogenic Factor 1 in the Ventromedial Nucleus of the Hypothalamus Regulates Age-Dependent Obesity.

 Ann W. Kinyua  ;  Dong Joo Yang  ;  Inik Chang  ;  Ki Woo Kim 
 PLOS ONE, Vol.11(9) : e0162352, 2016 
Journal Title
Issue Date
Adipose Tissue, Brown/metabolism ; Adipose Tissue, Brown/pathology ; Aging/genetics* ; Aging/metabolism ; Aging/pathology ; Animals ; Blood Glucose/metabolism ; Diet, High-Fat/adverse effects ; Eating/genetics ; Energy Metabolism/physiology ; Gene Expression Regulation ; Glucose Transporter Type 2/genetics ; Glucose Transporter Type 2/metabolism ; Homeostasis/physiology ; Insulin/blood ; Insulin/genetics* ; Leptin/genetics* ; Leptin/metabolism ; Male ; Mice ; Mice, Knockout ; Obesity/etiology ; Obesity/genetics* ; Obesity/metabolism ; Obesity/physiopathology ; Oxygen Consumption/physiology ; Signal Transduction ; Steroidogenic Factor 1/deficiency ; Steroidogenic Factor 1/genetics* ; Ventromedial Hypothalamic Nucleus/metabolism* ; Ventromedial Hypothalamic Nucleus/physiopathology
The ventromedial nucleus of the hypothalamus (VMH) is important for the regulation of whole body energy homeostasis and lesions in the VMH are reported to result in massive weight gain. The nuclear receptor steroidogenic factor 1 (SF-1) is a known VMH marker as it is exclusively expressed in the VMH region of the brain. SF-1 plays a critical role not only in the development of VMH but also in its physiological functions. In this study, we generated prenatal VMH-specific SF-1 KO mice and investigated age-dependent energy homeostasis regulation by SF-1. Deletion of SF-1 in the VMH resulted in dysregulated insulin and leptin homeostasis and late onset obesity due to increased food intake under normal chow and high fat diet conditions. In addition, SF-1 ablation was accompanied by a marked reduction in energy expenditure and physical activity and this effect was significantly pronounced in the aged mice. Taken together, our data indicates that SF-1 is a key component in the VMH-mediated regulation of energy homeostasis and implies that SF-1 plays a protective role against metabolic stressors including aging and high fat diet.
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2. College of Dentistry (치과대학) > Dept. of Oral Biology (구강생물학교실) > 1. Journal Papers
Yonsei Authors
Chang, In Ik(장인익)
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