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Pattern of late gadolinium enhancement predicts arrhythmic events in patients with non-ischemic cardiomyopathy

DC Field Value Language
dc.contributor.author김영진-
dc.contributor.author이혜정-
dc.contributor.author정보영-
dc.contributor.author박희남-
dc.contributor.author신동금-
dc.contributor.author엄재선-
dc.contributor.author이문형-
dc.date.accessioned2017-10-26T07:33:21Z-
dc.date.available2017-10-26T07:33:21Z-
dc.date.issued2016-
dc.identifier.issn0167-5273-
dc.identifier.urihttps://ir.ymlib.yonsei.ac.kr/handle/22282913/152187-
dc.description.abstractBACKGROUND: Left ventricular late gadolinium enhancement (LV-LGE) by cardiac magnetic resonance (CMR) imaging has been associated with adverse clinical outcomes in patients with non-ischemic cardiomyopathy (NICM). However, an association between the characteristics of the LGE and arrhythmic risk has not been demonstrated consistently. This study evaluated the impact of the LV-LGE characteristics on the arrhythmia risk in patients with NICM. METHODS: This study enrolled 365 consecutive patients (54±15years) with NICM who underwent CMR imaging. All patients were monitored for the following outcomes: major arrhythmic events (MA), including sustained ventricular tachycardia, an appropriate implantable cardioverter-defibrillator intervention, ventricular fibrillation and sudden cardiac death. RESULTS: During 44.3±36.4months of follow-up, 44 (12.1%) patients experienced MA. LV-LGE was observed in 40 (90.9%) and 221 (68.8%) patients with and without MA, respectively. LV-LGE was more frequently observed in the MA group (p=0.002). The age- and sex-adjusted hazard ratio (HR) of MA was increased in patients with LGE extent≥8% (HR 8.45, 95% confidence interval (CI) 2.91-24.6), and those with subendocardial (HR 6.98, 95% CI 1.74-28.0) and subepicardial LGE patterns (HR 7.2, 95% CI 1.61-35.6). In multivariable models adjusted for other clinical variables, only the subepicardial LGE pattern had 7.2 (95% CI, 1.61-32.6, p=0.01) time increase in the MA risk. CONCLUSIONS: LV-LGE in patients with NICM is not uncommon. The subepicardial pattern of the LV-LGE was an independent predictor of MA, suggesting that specific patterns of the LV-LGE are closely related to the severity of arrhythmic events.-
dc.description.statementOfResponsibilityrestriction-
dc.languageEnglish-
dc.publisherElsevier-
dc.relation.isPartOfINTERNATIONAL JOURNAL OF CARDIOLOGY-
dc.rightsCC BY-NC-ND 2.0 KR-
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/2.0/kr/-
dc.subject.MESHAdult-
dc.subject.MESHAged-
dc.subject.MESHArrhythmias, Cardiac/diagnosis*-
dc.subject.MESHArrhythmias, Cardiac/etiology-
dc.subject.MESHArrhythmias, Cardiac/mortality-
dc.subject.MESHArrhythmias, Cardiac/therapy-
dc.subject.MESHCardiomyopathies*/complications-
dc.subject.MESHCardiomyopathies*/diagnosis-
dc.subject.MESHCardiomyopathies*/physiopathology-
dc.subject.MESHDeath, Sudden, Cardiac/epidemiology-
dc.subject.MESHDeath, Sudden, Cardiac/prevention & control-
dc.subject.MESHFemale-
dc.subject.MESHGadolinium/pharmacology-
dc.subject.MESHHeart Ventricles*/drug effects-
dc.subject.MESHHeart Ventricles*/physiopathology-
dc.subject.MESHHumans-
dc.subject.MESHImage Enhancement/methods-
dc.subject.MESHMagnetic Resonance Imaging, Cine/methods-
dc.subject.MESHMale-
dc.subject.MESHMiddle Aged-
dc.subject.MESHPredictive Value of Tests-
dc.subject.MESHPrognosis-
dc.subject.MESHRadioisotopes-
dc.subject.MESHRepublic of Korea/epidemiology-
dc.subject.MESHRisk Assessment/methods-
dc.titlePattern of late gadolinium enhancement predicts arrhythmic events in patients with non-ischemic cardiomyopathy-
dc.typeArticle-
dc.publisher.locationNetherlands-
dc.contributor.collegeCollege of Medicine-
dc.contributor.departmentDept. of Radiology-
dc.contributor.googleauthorDong Geum Shin-
dc.contributor.googleauthorHye-Jeong Lee-
dc.contributor.googleauthorJunbeom Park-
dc.contributor.googleauthorJae-Sun Uhm-
dc.contributor.googleauthorHui-Nam Pak-
dc.contributor.googleauthorMoon-Hyoung Lee-
dc.contributor.googleauthorYoung Jin Kim-
dc.contributor.googleauthorBoyoung Joung-
dc.identifier.doi10.1016/j.ijcard.2016.07.122-
dc.contributor.localIdA03320-
dc.contributor.localIdA03609-
dc.contributor.localIdA01776-
dc.contributor.localIdA02090-
dc.contributor.localIdA02337-
dc.contributor.localIdA02766-
dc.contributor.localIdA00727-
dc.relation.journalcodeJ01093-
dc.identifier.eissn1874-1754-
dc.identifier.pmid27458824-
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0167527316314723?via%3Dihub-
dc.subject.keywordArrhythmic events-
dc.subject.keywordCardiac MRI-
dc.subject.keywordLate gadolinium enhancement-
dc.subject.keywordNonischemic cardiomyopathy-
dc.subject.keywordPredictor-
dc.contributor.alternativeNameKim, Young Jin-
dc.contributor.alternativeNameLee, Hye Jeong-
dc.contributor.alternativeNameJoung, Bo Young-
dc.contributor.alternativeNamePak, Hui Nam-
dc.contributor.alternativeNameShin, Dong Geum-
dc.contributor.alternativeNameUhm, Jae Sun-
dc.contributor.alternativeNameLee, Moon Hyoung-
dc.contributor.affiliatedAuthorLee, Hye Jeong-
dc.contributor.affiliatedAuthorJoung, Bo Young-
dc.contributor.affiliatedAuthorPak, Hui Nam-
dc.contributor.affiliatedAuthorShin, Dong Geum-
dc.contributor.affiliatedAuthorUhm, Jae Sun-
dc.contributor.affiliatedAuthorLee, Moon Hyoung-
dc.contributor.affiliatedAuthorKim, Young Jin-
dc.citation.volume222-
dc.citation.startPage9-
dc.citation.endPage15-
dc.identifier.bibliographicCitationINTERNATIONAL JOURNAL OF CARDIOLOGY, Vol.222 : 9-15, 2016-
dc.date.modified2017-10-24-
dc.identifier.rimsid46965-
dc.type.rimsART-
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Radiology (영상의학교실) > 1. Journal Papers

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