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Prognostic value of FDG-PET volumetric parameters in patients with p16-positive oropharyngeal squamous cell carcinoma who received curative resection followed by postoperative radiotherapy or chemoradiotherapy

Authors
 Kyung Hwan Kim  ;  Jeongshim Lee  ;  Jee Suk Chang  ;  Chang Geol Lee  ;  Mijin Yun  ;  Eun Chang Choi  ;  Se-Heon Kim  ;  Ki Chang Keum 
Citation
 Head & Neck, Vol.38(10) : 1515-1524, 2016 
Journal Title
 Head & Neck 
ISSN
 1043-3074 
Issue Date
2016
MeSH
Aged ; Carcinoma, Squamous Cell/diagnostic imaging* ; Carcinoma, Squamous Cell/mortality ; Carcinoma, Squamous Cell/secondary ; Carcinoma, Squamous Cell/therapy ; Chemoradiotherapy ; Combined Modality Therapy ; Disease-Free Survival ; Female ; Fluorodeoxyglucose F18 ; Humans ; Kaplan-Meier Estimate ; Male ; Middle Aged ; Oropharyngeal Neoplasms/diagnostic imaging* ; Oropharyngeal Neoplasms/mortality ; Oropharyngeal Neoplasms/pathology ; Oropharyngeal Neoplasms/therapy ; Positron-Emission Tomography* ; Prognosis ; Radiotherapy ; Retrospective Studies ; Tumor Burden
Keywords
metabolic tumor volume ; oropharyngeal cancer ; p16-positive ; postoperative radiotherapy ; total lesion glycolysis
Abstract
BACKGROUND: The purpose of this study was to determine whether pretreatment 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) volumetric parameters add more prognostic information to p16-positive oropharyngeal squamous cell carcinoma (SCC). METHODS: We retrospectively analyzed 86 patients with p16-positive oropharyngeal SCC who underwent surgery and postoperative radiotherapy (RT) or chemoradiotherapy (CRT). Maximum standardized uptake value (SUVmax ), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured. RESULTS: Higher total MTV (tMTV), nodal MTV (nMTV), and tumor TLG (tTLG) were significantly associated with lower disease-free survival (DFS) (all p < .05) and higher distant metastasis rates (all p < .05). Multivariate analysis of DFS revealed that tMTV (p = .032), nMTV (p = .004), and tTLG (p = .018) were independently significant prognosticators. CONCLUSION: Patients with p16-positive disease with high metabolic tumor burden were associated with higher distant metastasis rates, translating into worse survival. These patients may not be optimal candidates for treatment deintensification.
Full Text
http://onlinelibrary.wiley.com/doi/10.1002/hed.24465/abstract
DOI
10.1002/hed.24465
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Radiation Oncology (방사선종양학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Otorhinolaryngology (이비인후과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
금기창(Keum, Ki Chang) ORCID logo https://orcid.org/0000-0003-4123-7998
김세헌(Kim, Se Heon)
윤미진(Yun, Mi Jin) ORCID logo https://orcid.org/0000-0002-1712-163X
이정심(Lee, Jeong Shim)
이창걸(Lee, Chang Geol) ORCID logo https://orcid.org/0000-0002-8702-881X
장지석(Chang, Jee Suk Paul) ORCID logo https://orcid.org/0000-0001-7685-3382
최은창(Choi, Eun Chang)
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152158
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