Cited 12 times in
Prognostic value of FDG-PET volumetric parameters in patients with p16-positive oropharyngeal squamous cell carcinoma who received curative resection followed by postoperative radiotherapy or chemoradiotherapy
DC Field | Value | Language |
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dc.contributor.author | 금기창 | - |
dc.contributor.author | 김세헌 | - |
dc.contributor.author | 윤미진 | - |
dc.contributor.author | 이정심 | - |
dc.contributor.author | 이창걸 | - |
dc.contributor.author | 장지석 | - |
dc.contributor.author | 최은창 | - |
dc.date.accessioned | 2017-10-26T07:32:09Z | - |
dc.date.available | 2017-10-26T07:32:09Z | - |
dc.date.issued | 2016 | - |
dc.identifier.issn | 1043-3074 | - |
dc.identifier.uri | https://ir.ymlib.yonsei.ac.kr/handle/22282913/152158 | - |
dc.description.abstract | BACKGROUND: The purpose of this study was to determine whether pretreatment 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) volumetric parameters add more prognostic information to p16-positive oropharyngeal squamous cell carcinoma (SCC). METHODS: We retrospectively analyzed 86 patients with p16-positive oropharyngeal SCC who underwent surgery and postoperative radiotherapy (RT) or chemoradiotherapy (CRT). Maximum standardized uptake value (SUVmax ), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were measured. RESULTS: Higher total MTV (tMTV), nodal MTV (nMTV), and tumor TLG (tTLG) were significantly associated with lower disease-free survival (DFS) (all p < .05) and higher distant metastasis rates (all p < .05). Multivariate analysis of DFS revealed that tMTV (p = .032), nMTV (p = .004), and tTLG (p = .018) were independently significant prognosticators. CONCLUSION: Patients with p16-positive disease with high metabolic tumor burden were associated with higher distant metastasis rates, translating into worse survival. These patients may not be optimal candidates for treatment deintensification. | - |
dc.description.statementOfResponsibility | restriction | - |
dc.language | English | - |
dc.publisher | John Wiley And Sons | - |
dc.relation.isPartOf | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | - |
dc.rights | CC BY-NC-ND 2.0 KR | - |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/2.0/kr/ | - |
dc.subject.MESH | Aged | - |
dc.subject.MESH | Carcinoma, Squamous Cell/diagnostic imaging* | - |
dc.subject.MESH | Carcinoma, Squamous Cell/mortality | - |
dc.subject.MESH | Carcinoma, Squamous Cell/secondary | - |
dc.subject.MESH | Carcinoma, Squamous Cell/therapy | - |
dc.subject.MESH | Chemoradiotherapy | - |
dc.subject.MESH | Combined Modality Therapy | - |
dc.subject.MESH | Disease-Free Survival | - |
dc.subject.MESH | Female | - |
dc.subject.MESH | Fluorodeoxyglucose F18 | - |
dc.subject.MESH | Humans | - |
dc.subject.MESH | Kaplan-Meier Estimate | - |
dc.subject.MESH | Male | - |
dc.subject.MESH | Middle Aged | - |
dc.subject.MESH | Oropharyngeal Neoplasms/diagnostic imaging* | - |
dc.subject.MESH | Oropharyngeal Neoplasms/mortality | - |
dc.subject.MESH | Oropharyngeal Neoplasms/pathology | - |
dc.subject.MESH | Oropharyngeal Neoplasms/therapy | - |
dc.subject.MESH | Positron-Emission Tomography* | - |
dc.subject.MESH | Prognosis | - |
dc.subject.MESH | Radiotherapy | - |
dc.subject.MESH | Retrospective Studies | - |
dc.subject.MESH | Tumor Burden | - |
dc.title | Prognostic value of FDG-PET volumetric parameters in patients with p16-positive oropharyngeal squamous cell carcinoma who received curative resection followed by postoperative radiotherapy or chemoradiotherapy | - |
dc.type | Article | - |
dc.publisher.location | United States | - |
dc.contributor.college | College of Medicine | - |
dc.contributor.department | Dept. of Radiation Oncology | - |
dc.contributor.googleauthor | Kyung Hwan Kim | - |
dc.contributor.googleauthor | Jeongshim Lee | - |
dc.contributor.googleauthor | Jee Suk Chang | - |
dc.contributor.googleauthor | Chang Geol Lee | - |
dc.contributor.googleauthor | Mijin Yun | - |
dc.contributor.googleauthor | Eun Chang Choi | - |
dc.contributor.googleauthor | Se-Heon Kim | - |
dc.contributor.googleauthor | Ki Chang Keum | - |
dc.identifier.doi | 10.1002/hed.24465 | - |
dc.contributor.localId | A00605 | - |
dc.contributor.localId | A02550 | - |
dc.contributor.localId | A03112 | - |
dc.contributor.localId | A03240 | - |
dc.contributor.localId | A04658 | - |
dc.contributor.localId | A04161 | - |
dc.contributor.localId | A00272 | - |
dc.relation.journalcode | J00963 | - |
dc.identifier.eissn | 1097-0347 | - |
dc.identifier.pmid | 27062085 | - |
dc.identifier.url | http://onlinelibrary.wiley.com/doi/10.1002/hed.24465/abstract | - |
dc.subject.keyword | metabolic tumor volume | - |
dc.subject.keyword | oropharyngeal cancer | - |
dc.subject.keyword | p16-positive | - |
dc.subject.keyword | postoperative radiotherapy | - |
dc.subject.keyword | total lesion glycolysis | - |
dc.contributor.alternativeName | Keum, Ki Chang | - |
dc.contributor.alternativeName | Kim, Se Heon | - |
dc.contributor.alternativeName | Yun, Mi Jin | - |
dc.contributor.alternativeName | Lee, Jeong Shim | - |
dc.contributor.alternativeName | Lee, Chang Geol | - |
dc.contributor.alternativeName | Chang, Jee Suk Paul | - |
dc.contributor.alternativeName | Choi, Eun Chang | - |
dc.contributor.affiliatedAuthor | Kim, Se Heon | - |
dc.contributor.affiliatedAuthor | Yun, Mi Jin | - |
dc.contributor.affiliatedAuthor | Lee, Jeong Shim | - |
dc.contributor.affiliatedAuthor | Lee, Chang Geol | - |
dc.contributor.affiliatedAuthor | Chang, Jee Suk Paul | - |
dc.contributor.affiliatedAuthor | Choi, Eun Chang | - |
dc.contributor.affiliatedAuthor | Keum, Ki Chang | - |
dc.citation.volume | 38 | - |
dc.citation.number | 10 | - |
dc.citation.startPage | 1515 | - |
dc.citation.endPage | 1524 | - |
dc.identifier.bibliographicCitation | HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK, Vol.38(10) : 1515-1524, 2016 | - |
dc.date.modified | 2017-10-24 | - |
dc.identifier.rimsid | 46937 | - |
dc.type.rims | ART | - |
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