156 211

Cited 28 times in

Prognostic Significance of ¹?F-FDG Uptake in Hepatocellular Carcinoma Treated with Transarterial Chemoembolization or Concurrent Chemoradiotherapy: A Multicenter Retrospective Cohort Study

 Jeong Won Lee  ;  Jin Kyoung Oh  ;  Yong An Chung  ;  Sae Jung Na  ;  Seung Hyup Hyun  ;  Il Ki Hong  ;  Jae Seon Eo  ;  Bong-Il Song  ;  Tae-sung Kim  ;  Do Young Kim  ;  Seung Up Kim  ;  Dae Hyuk Moon  ;  Jong Doo Lee  ;  Mijin Yun 
 JOURNAL OF NUCLEAR MEDICINE, Vol.57(4) : 509-516, 2016 
Journal Title
Issue Date
Adult ; Aged ; Aged, 80 and over ; Aging/metabolism ; Carcinoma, Hepatocellular/metabolism* ; Carcinoma, Hepatocellular/radiotherapy ; Carcinoma, Hepatocellular/therapy* ; Chemoradiotherapy ; Cohort Studies ; Disease-Free Survival ; Embolization, Therapeutic ; Female ; Fluorodeoxyglucose F18/metabolism* ; Humans ; Image Processing, Computer-Assisted ; Liver/metabolism ; Liver Neoplasms/metabolism* ; Liver Neoplasms/radiotherapy ; Liver Neoplasms/therapy* ; Male ; Middle Aged ; Neoplasm Metastasis ; Predictive Value of Tests ; Prognosis ; Radiopharmaceuticals/metabolism* ; Retrospective Studies ; Survival Analysis
18F-FDG PET ; concurrent chemoradiotherapy ; hepatocellular carcinoma ; prognosis ; transarterial chemoembolization
This study aimed to assess the prognostic value of (18)F-FDG uptake in hepatocellular carcinoma (HCC) patients who had transarterial chemoembolization (TACE) or concurrent intraarterial chemotherapy with external-beam radiotherapy (CCRT) and to compare the prognosis between patients treated with TACE and those with CCRT according to (18)F-FDG uptake. METHODS: Two hundred fourteen intermediate-to-advanced-stage HCC patients without extrahepatic metastasis who underwent staging (18)F-FDG PET/CT before TACE (153 patients) or CCRT (61 patients) were recruited from 7 hospitals. Progression-free survival (PFS) and overall survival (OS) were compared using an optimal cutoff value for tumor-to-normal liver uptake ratio (TLR). Further, PFS and OS were compared according to treatment modalities (TACE vs. CCRT) using the same TLR cutoff value. RESULTS: On multivariate analysis, age and TLR were independent prognostic factors for PFS (P< 0.050). For OS, Child-Pugh classification and TLR were independent prognostic factors (P< 0.050). When the TLR was greater than 2.0, patients treated with CCRT showed significantly better PFS and OS than those treated with TACE after adjusting for tumor size and number (P= 0.014, for all). In contrast, there was no significant difference in PFS and OS between patients treated with TACE or CCRT when the TLR was 2.0 or less. CONCLUSION: (18)F-FDG uptake was an independent prognostic factor for PFS and OS in HCC patients treated with TACE or CCRT. Especially, in HCCs with high (18)F-FDG uptake, patients treated with CCRT showed better survival than those treated with TACE. (18)F-FDG PET/CT may help determine the treatment modality for intermediate-to-advanced-stage HCCs.
Files in This Item:
T201603733.pdf Download
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Internal Medicine (내과학교실) > 1. Journal Papers
1. College of Medicine (의과대학) > Dept. of Nuclear Medicine (핵의학교실) > 1. Journal Papers
Yonsei Authors
Kim, Do Young(김도영)
Kim, Seung Up(김승업) ORCID logo https://orcid.org/0000-0002-9658-8050
Yun, Mi Jin(윤미진) ORCID logo https://orcid.org/0000-0002-1712-163X
사서에게 알리기


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.