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Association of miR-146a, miR-149, miR-196a2, and miR-499 Polymorphisms with Ossification of the Posterior Longitudinal Ligament of the Cervical Spine

Authors
 Jae Joon Lim  ;  Dong Ah Shin  ;  Young Joo Jeon  ;  Hemant Kumar  ;  Seil Sohn  ;  Hyoung Sik Min  ;  Jang Bo Lee  ;  Sung Uk Kuh  ;  Keung Nyun Kim  ;  Jung Oh Kim  ;  Ok Joon Kim  ;  Alexander E. Ropper  ;  Nam Keun Kim  ;  InBo Han 
Citation
 PLoS One, Vol.11(7) : e0159756, 2016 
Journal Title
 PLoS One 
Issue Date
2016
MeSH
Adult ; Aged ; Alleles ; Asian Continental Ancestry Group/genetics ; Case-Control Studies ; Cervical Vertebrae* ; Female ; Gene Frequency ; Genetic Predisposition to Disease ; Genotype ; Haplotypes ; Humans ; Male ; MicroRNAs/chemistry ; MicroRNAs/genetics* ; Middle Aged ; Ossification of Posterior Longitudinal Ligament/genetics* ; Polymorphism, Single Nucleotide* ; Republic of Korea
Abstract
BACKGROUND: Ossification of the posterior longitudinal ligament (OPLL) of the spine is considered a multifactorial and polygenic disease. We aimed to investigate the association between four single nucleotide polymorphisms (SNPs) of pre-miRNAs [miR-146aC>G (rs2910164), miR-149T>C (rs2292832), miR-196a2T>C (rs11614913), and miR-499A>G (rs3746444)] and the risk of cervical OPLL in the Korean population. METHODS: The genotypic frequencies of these four SNPs were analyzed in 207 OPLL patients and 200 controls by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) assay. FINDINGS: For four SNPs in pre-miRNAs, no significant differences were found between OPLL patients and controls. However, subgroup analysis based on OPLL subgroup (continuous: continuous type plus mixed type, segmental: segmental and localized type) showed that miR-499GG genotype was associated with an increased risk of segmental type OPLL (adjusted odds ratio = 4.314 with 95% confidence interval: 1.109-16.78). In addition, some allele combinations (C-T-T-G, G-T-T-A, and G-T-C-G of miR-146a/-149/-196a2/-499) and combined genotypes (miR-149TC/miR-196a2TT) were associated with increased OPLL risk, whereas the G-T-T-G and G-C-C-G allele combinations were associated with decreased OPLL risk. CONCLUSION: The results indicate that GG genotype of miR-499 is associated with significantly higher risks of OPLL in the segmental OPLL group. The miR-146a/-149/-196a2/-499 allele combinations may be a genetic risk factor for cervical OPLL in the Korean population.
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DOI
10.1371/journal.pone.0159756
Appears in Collections:
1. College of Medicine (의과대학) > Dept. of Neurosurgery (신경외과학교실) > 1. Journal Papers
Yonsei Authors
구성욱(Kuh, Sung Uk) ORCID logo https://orcid.org/0000-0003-2566-3209
김긍년(Kim, Keung Nyun)
신동아(Shin, Dong Ah) ORCID logo https://orcid.org/0000-0002-5225-4083
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URI
https://ir.ymlib.yonsei.ac.kr/handle/22282913/152145
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